What a coincidence🤔. Uri Galili argues how anti-carbohydrate antibodies helped to prevent extinction of primate species caused by deadly viruses. α-gal epitope (how else ?), Bombay, Neu5Gc. bit.ly/3rquD51 #glycotime

Great article Pawel Burkhardt explains how the nervous system has evolved and why ctenophores (comb jellies) are great model to study evolutionary origins of neurons @Sars_Centre bit.ly/3rtTGUL

Interesting study shows that alpha-1,6 fucosyltransferase 8 (FUT8) stem region is essential for multimer formation but not for catalytic activity. Loss of the stem region destabilizes the FUT8 protein. Journal of Biological Chemistry bit.ly/3WCa9EE #glycotime

Today, Krzysiek Mikołajczyk defended with honors his Ph.D. Thesis IITD. Subject: how presence of N-glycans influences the activity of human Gb3/CD77 synthase (A4GALT). Congratulations Krzysztof! tinyurl.com/5y9z455e tinyurl.com/bdfrjrzf #glycotime

Interesting article about perinatal manifestations in congenital disorders of glycosylation (CDG) with an eye on early diagnosis. Milena Greczan tinyurl.com/58r8srv7 #glycotime #CDG

Hypothesis: why morbidity and mortality due to SARS-COV-2 infection were lower in lake-rich regions? Is it possible that lectin-like substances associated with phytoplankton/zooplankton in the atmosphere caused inactivation of virus particles? tinyurl.com/ycku2zkk #glycotime

Zapowiadałem wczoraj niezwykle ciekawy tekst o układzie nerwowym (pierwszy z cyklu). Oto i on. Czytajcie, retwittujcie, rozpowszechniajcie, bo naprawdę warto. eksperymentmyslowy.pl/2023/04/24/jak…

Prolactin-induced protein (PIP), small secreted glycoprotein carrying several N-glycans, up-regulates the expression of pro-apoptotic genes, increasing the sensitivity of breast cancer cells to drug-induced apoptosis. Katarzyna Szymczak tinyurl.com/2s3das85 #glycotime

I invite all interested in glycobiology to the conference "Paths of Glycobiology", which will take place IITD in Wrocław, 28-29.09.2023. Among invited speakers: Elisa Fadda, Francis Jacob, Iain Wilson. Please register: tinyurl.com/ae9wkt79 There is no fee! #glycotime

Why coagulation Factor VIII allo-antibodies arise in 30% of patients during replacement therapy? A select set of anatomically distinct antigen presenting cells along with innate immune signaling is to blame. A landmark paper by Radoslaw Kaczmarek @BloodJournal tinyurl.com/yu7rjkt8

Parkinson's disease: oligosaccharide fragment of GM1 ganglioside directly interacts with α-synuclein, inhibits its aggregation, protects neurons from α-synuclein toxicity and inflammation Maria Fazzari tinyurl.com/5ba969zs #glycotime

Interesting review on blood groups in the context of anthropology: how ethnicity should be considered in transfusion medicine. Great historical background, too. tinyurl.com/zu84ajj8 #blood_transfusion

Interesting summary about new blood groups and antigens described in the last 20 years (🔒) tinyurl.com/3dz54cc4 #blood_groups

Another interesting discovery from Angelo D'Alessandro: L-carnitine as an important factor in RBC metablism. Supplementation of stored RBCs with L-carnitine as a strategy to improve RBC storage quality? tinyurl.com/yjkmwskc

Comprehensive lipidomic analysis of the genus Cutibacterium (eg C. acnes, C. granulosum): 128 lipids identified, incl. markers as phosphatidylcholine PC 30:0, sphingomyelins 33:1, 35:1) and phosphatidylglycerol with an alkyl ether substituent PG O-32:0. tinyurl.com/tjfkxz2z

Interesting review about inhibitors of Shiga toxins. As traditional antibiotcs cannot be used, small inhibitors such as blockers of retrograde transport emerge as prospective drugs, especially in hemolytic uremic syndrome. tinyurl.com/3mna7dms #glycotime

Another important paper from Krzysiek Mikołajczyk and Sebastian Kmiecik: how heterodimerization with β1,4-galactosyltransferases 1 and 5 (B4galt1/5) influences dual acceptor specificity (GP vs GSL) of Gb3/CD77 synthase (human α1,4-galactosyltransferase, A4galt) tinyurl.com/bdzn9mbk #glycotime

Important paper Krzysiek Mikołajczyk Sebastian Kmiecik now in the final version: dual specificity of human α1,4-GAL-transferase (GSL/GP) is caused by heterodimerization with GP-specific β1,4-GAL-transferase 1 (B4galt1) and GSL-specific β1,4-GAL-transferases 5/6 tinyurl.com/3ejbhkb4 #glycotime

New paper describing the properties of yolkin, a cytokine-inducing polypeptide from egg yolk. Katarzyna Szymczak perfomed glycan characterization. tinyurl.com/yx57urxd

A mysterious case of hypersensitivity pneumonitis among sawmill woodworkers in Bełżec, Lublin voivodeship solved: novel bacterium, Microbacterium betulae sp. nov., which thrives in sapwood (phloem) tissue of birch trees (Betula pendula) tinyurl.com/27k53h7w