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Cryo-EM structure of the mitochondrial protein-import channel TOM complex from Saccharomyces cerevisiae. biorxiv.org/cgi/content/sh… #bioRxiv

First graduate project published after such a long arduous journey 👴🏾👴🏾👴🏾👴🏾 #tomcomplex #mitochondria #proteinimport #cryoem #nearatomic #outhereinthesestreets nature.com/articles/s4159…

Excited to share this new story from our lab, characterizing the structure and function of the 3a ion channel of SARS-CoV-2! biorxiv.org/node/1372064

SARS-CoV-2 3a preprint update, 2.1Å! map with Abhay Kotecha Thermo Fisher, processed by me and Christopher Hoel. We now have new PL uptake assays and RuR as an inhibitor from sonali mali (Bautista Lab) and new 3a mutants patched by Ben Sorum. Led by Steve Brohawn biorxiv.org/content/10.110…

First paper from my little brother. I won't claim to have a strong understanding of QTLs, evolution, trans regulatory elements, etc... So my take home is that Biochemistry > Genetics once again :)

New preprint!! Cryo-EM structure SARS-CoV-2 M (50 kDa!) and MD sims give insight into M's essential role in virus assembly and evolutionary relationship with SARS-CoV-2 ORF3a viroporin. Led by Kim Dolan w/ David Kern, Mandira Dutta+@vothlab, and Abhay Kotecha! biorxiv.org/content/10.110…

New preprint! Christopher Hoel+Lin Zhang solved a cryo-EM structure of the 7TM TMEM87A + found (surprise!) it's related to the Wnt chaperone Wntless+6 other proteins (thx #alphafold!), suggesting a shared role for "GOSTs" in trafficking greasy/secreted cargo. biorxiv.org/content/10.110…

New preprint! LRRC8A:C structures show how heteromeric volume-reg’d anion channels form + function with pore-embedded lipids to gate closed🤯 Truly impressive work led by David Kern + great collabs w/ Julia Bleier @IsacoffLab Somnath Mukherjee+Kossiakoff lab! biorxiv.org/content/10.110…

I once thought of ion channels as protein tunnels, built to exclude the membrane. Fitting that the one @stevebrohawn and I chose to study contains internal lipids central to channel function. Preprint on the LRRC8A:C volume-regulated anion channel: doi.org/10.1101/2022.0…

My project is finally out! First ever cryo-EM structure of channelrhodopsin in a lipid nanodisc (I think?). So grateful for my amazing graduate mentor Steve Brohawn, welcoming me into the lab and encouraging me every step of the way! Read more below: nature.com/articles/s4146…