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Looking for a post doc to join the team. Hypoxia, inflammation and endometrium in beautiful Edinburgh. Interested? Would love to hear from you. jobs.ac.uk/search/?keywor… ESHRE SSR SRI @SRF_Repro Early Career Endos

Check out our latest preprint on bioRxiv on the role of #lncRNAs in cell division.biorxiv.org/content/10.110… … Great collaboration with Aaron Lun, Mascalchi Patrice Christina Ernst @Alexis_Barr @BakalLabICR MarioniLab Duncan Odom & Omar Apes

(1/4) Check out our latest work on GOT1 metabolism in pancreatic cancer #Preprint #OpenAccess bioRxiv!

Judith Pape passed her viva! Congrats to this successful researcher!

Congratulations to past Keun Lab member Judith Pape for passing her PhD viva! 3D Models of Health and Disease #PhD #congratulations

Our latest paper where we studied which microRNAs can be measured stably over time in serum, a factor in making them good biomarker candidates. What we found was a surprising link to maternally imprinted genes #geneimprinting #microRNAs #biomarkers nature.com/articles/s4159…

Japan: Intercellular signal transduction during the assembly of slime mould cells • cAMP-sensitive fluorescent probes • signal is transmitted as a spiral wave within the group • amazing • via Kota Miura dx.doi.org/10.1038/s42003…

Our latest paper in which we show that lactic acidosis protects cancer cells from cell death induced by the pan-Akt inhibitor uprosertib, and how the effect can be reversed by metabolic inhibitors #cancermetabolism #tumormicroenvironment #drugresistance rdcu.be/b2J1G

Recently published in British Journal of Cancer: Pre-clinical research demonstrates lactic acidosis in cancer induces Akt inhibitor resistance. Interfering with lactic acid uptake reversed resistance to the Akt inhibitor, uprosertib. Keun Lab Imperial College London go.nature.com/2IGGbud

A big moment for me - 20 years ago today I started at Imperial College London ! It has been a lot of fun, so lucky to have worked with so many brilliant and supportive colleagues. Thank you to all Keun Lab past and present👏you are amazing (And of course the best is yet to come... !)

Another PhD that'll be formally advertised soon - this time through STRATiGRAD Proj w/ Prof Iain McNeish Surgery and Cancer & AstraZeneca > biomarker discovery & instrument development for ovarian cancer. Interested or know anyone that might? Get in touch. RTs appreciated!

Distinguishing between vaccine efficacy and effectivenesss, looking at relative risk reduction (RRR), absolute risk reduction (ARR) and numbers needed to vaccinate (NNV) thelancet.com/journals/lanmi… The Lancet Microbe by Els Torreele UCL Institute for Innovation and Public Purpose and colleagues

How do #cancer cells that survive chemotherapy resolve stress? Turns out it’s complex & generates druggable weaknesses. See our new paper now out in PNAS (1/8).🧵pnas.org/content/118/17…

Very pleased to have contributed to this great paper from @auner_lab_ICL on stress resolution in multiple myeloma cells recovering from proteasome inhibition. Follow thread to find out out more 👇

An international research team, including Hector Keun and Alexandros SISKOS from S&C, has identified metabolic ‘signatures’ in urine that can determine the quality of diets in children across Europe and predict their metabolic health. imperial.ac.uk/news/233335/ur…

Reliable measurement of diet from self-report is notoriously difficult. Evidence from Born in Bradford & sister cohorts shows potential for urinary markers Urinary metabolic biomarkers of diet quality in European children are associated with metabolic health doi.org/10.7554/eLife.…

Our latest paper in which we show how targeting RNA splicing can impact tumour metabolism and could be a new way to treat an aggressive childhood cancer. Great collaboration with The ICR MRC Laboratory of Medical Sciences (LMS) Congrats to Dr Arti Sikka Anke Nijhuis and Orli Yogev nature.com/articles/s4146…

Our latest paper linking the #metabolome #epigenome and #transcriptome to the #exposome (chemicals, diet, environment) in six populations of children across Europe nature.com/articles/s4146…