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Happy to share our new review on molecular pharmacology of calcium-selective TRP channel TRPV6. @arthurCantab tandfonline.com/doi/full/10.10…

I'm happy to announce that v5 of🔬Follow Relion Gracefully is now live! This version provides a comprehensive dashboard for seamless interaction with your #cryoem data in Relion. Check it out: github.com/dzyla/Follow_R…

Happy to share our new paper on the structural basis of selective TRPM7 inhibition by the anticancer agent CCT128930. Collaboration between V. Chubanov, A. Sobolevsky Alexander Sobolevsky and M. Kurnikova Maria Kurnikova labs. Kirill Nadezhdin @arthurCantab cell.com/cell-reports/f…

Another great work by Vera Moiseenkova-Bell and Andreas Leffler groups - much needed data on TRPV2 acid sensitive. Functional and structural insights into activation of TRPV2 by weak acids | The EMBO Journal embopress.org/doi/full/10.10…

Happy to share the conformational ensemble of wild-type human TRPV3. For the first time the channel structure is open by applying agonists, 2-APB or THCV, without sensitizing mutations! Kirill Nadezhdin @arthurCantab Ira Talyzina science.org/doi/10.1126/sc…

First structures that illustrate opening of wild-type human TRPV3 (no sensitizing mutations!) by agonists, 2-APB or THCV, acting through different binding sites and expelling lipid from the vanilloid site. Kirill Nadezhdin @arthurCantab Ira Talyzina science.org/doi/10.1126/sc…

Happy to share the conformational ensemble of wild-type human TRPV3. For the first time the channel structure is open by applying agonists, 2-APB or THCV, without sensitizing mutations! Kirill Nadezhdin @arthurCantab Ira Talyzina science.org/doi/10.1126/sc…

Physiological temperature drives TRPM4 ligand recognition and gating. Congrats to the team! nature.com/articles/s4158…

Huang, Y., Kumar, S., Lee, J. et al. Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution | Nat Struct Mol Biol doi.org/10.1038/s41594…

Happy to share the first structure of kainate receptor channel in the open state. The channel was opened by agonist glutamate and positive allosteric modulators plant lectin Concanavalin A (ConA) and BPAM344. Shanti Pal Gangwar Maria Karela Kirill Nadezhdin disq.us/t/4oqzkgx

Happy to share our results on how the plant lectin Concanavalin A helped to open the channel of kainate receptor for the first time! Shanti Pal Gangwar Maria Karela Kirill Nadezhdin Laura Yen Maria Kurnikova disq.us/t/4oqzkgx

We solved several different states of the GluK2 (kainate) receptor using cryo-EM, including the open conformation 👇 rdcu.be/dINXB

Indeed, to assemble our in-house device, we used many ideas published by @cryoET (C-SPAM) in doi.org/10.1107/S20522… and by @RubinsteinJohn (Shake-it-off) in doi.org/10.1107/S20597…

Gain of function mutations in the TRPV4 #ionchannel cause a variety of musculoskeletal and neurological diseases, but the mechanism is unclear. A new paper shows the role of endothelial cells in blood-CNS barrier breakdown. science.org/doi/10.1126/sc…

Happy to share: Dynamic molecular portraits of ion-conducting pores characterize functional states of TRPV channels. Fantastic collaboration with the group of Roman Efremov! Kirill Nadezhdin @arthurCantab disq.us/t/4ox8tvi

Dynamic molecular portraits of ion-conducting pores characterize functional states of TRPV channels Kirill Nadezhdin @arthurCantab disq.us/t/4ox8tvi

To Get Images of This Fast-Acting Brain Protein, Scientists Had to Slow It Down Shanti Pal Gangwar Maria Karela Kirill Nadezhdin Laura Yen Maria Kurnikova cuimc.columbia.edu/news/get-image…

My first paper in Schwalbe Lab, to which I really contributed substantially is now online. A story about the FGFR receptor and it's inhibition by a small molecule in cells and in solution. [Spoiler] membrane matters! doi.org/10.1002/1873-3…

Happy to share our new review of TRP channel structural pharmacology that describes 40 sites of TRP channel regulation discovered by now! Ira Talyzina Kirill Nadezhdin sciencedirect.com/science/articl…

Forty sites of TRP channel regulation! A review of binding sites on TRP channels discovered by now. Ira Talyzina Kirill Nadezhdin sciencedirect.com/science/articl…