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Looking for the most effective ways to CRISPR edit human T cells? Look no further! Along with the team Penn we identified the engineering steps that control product function. Nearly 10 years of troubleshooting with Cas9 and novel base editors distilled down into 4 figures! (1/4)

What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design

It's even better than Prime Day! The 2024 HHMI #GilliamFellows have been named! We have two teams Penn Medicine Penn BGS Brie H-P & GB and Sam Preza & Juan Alvarez! Congratulations on your selection!

Thrilled to announce that my back-to-back co-first author papers are out today in nature! We present a long-term clinical study in patients and a preclinical study in mice, demonstrating the unexpected role of type-2 immunity in sustaining durable CAR T and ICB immunotherapies!

Beautiful work from our HorizonEU consortium led by Dimitrios L. Wagner and his world-class Berlin team. 90% CAR knock-in with ssDNA templates 😳 Almost couldn’t believe it until we independently produced a batch of ssDNA donor template and replicated it in our own lab. Preprint link 👇

This is absolutely wild!!

An absolutely bonkers stat from this Nature article on Nobel Prize winners. "702 out of 736 researchers who have won science and economics prizes up to 2023 are part of the same academic family" nature.com/immersive/d415…

Let's goooooooo Evan Weber!! We are so lucky to have you as our fearless leader!

😂 A true scientist passionately sharing their work with the audience!

I feel this

Spend some time in this thread. We need systemic change in public education now, & it's but a part of the problem of racism & misogyny. 👇🏽

In this new Review, Caroline Diorio, David Teachey & Stephan Grupp discuss the progress made and remaining roadblocks with allogeneic CAR cell therapies for cancer: nature.com/articles/s4157…

If only we had data on vaccine efficacy IF ONLY WE HAD THE DATA #vaccineswork

Excited to share our latest work in Nature Cancer to get a better understanding why relapsed T-ALL is so deadly and potential target strategies, led by Jason Xu and @changya1 with members of David Teachey, @junjyang, Charles Mullighan and many great colleagues. twtr.to/foS9o.

Patient-derived glioblastoma organoids as real-time avatars for assess... sciencedirect.com/science/articl… Happy to report our work using #GBM organoids to predict #CART response in #glioblastoma Penn Medicine - Abramson Cancer Center

Thanks for the shout out, Evan! I'm so honored to work with Cancer Research Institute, and psyched to get started on these experiments!

This is terrifying, heartbreaking, infuriating.