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Primary Oropharyngeal SMARCA4-Deficient Carcinoma: Expanding the Diagnostic Spectrum in Head and Neck Cancer S Pasricha, S Goyal, M Kamboj, H Diwan, M Gairola, et al rdcu.be/dS6ew #HeadNeckPathol #HNPJ #HeadandNeckPath #Pathology #ENTPath #PathologyTweet

Example of mixed cellularity classic Hodgkin lymphoma (Figure 1) with an otherwise classic phenotype (Figure 2: CD30+ PAX5 dim+ CD45- CD79a-), but with increased B-cell marker expression (Figure 3: CD20+ BOB+ OCT2+) and EBER positvity (Figure 4), in the setting of immune

This is a fantastic review of emerging mesenchymal tumours with unique fusions. Here is a peek into four of these entities. bit.ly/4dOFpri

🔬 Clonal dynamics in follicular lymphoma (FL) over time! 76 biopsies were analyzed from 25 pts using NGS to track mutations across disease progression & histological transformation (HT). Key findings: 🧬 40% of mutations remained stable over ~11.5 yrs 🔑 KMT2D & CREBBP—most

This gastroesophageal junctional tumor is a nasty one. The "bitten bagel" cell (arrow) and macronucleoli are clues to add the staining. Neil AJ, et al. SMARCA4 Mutations in Carcinomas of the Esophagus, Esophagogastric Junction, and Stomach. Mod Pathol. 2023 Jun;36(6):100183.

Juvenile Active Ossifying Fibroma (trabecular variant) Benign fibroosseous neoplasm composed of mixture of stroma and bone characterized by rapid growth • PsOF: Age range: 3 months to 72 years; mean: 16-33 years  Paranasal sinuses (~ 90%): Ethmoid > frontal > maxillary >

RAF1‐rearranged spindle cell neoplasm: a clinicopathological and molecular genetic study of six cases with review of the literature - Zhu - Histopathology - Wiley Online Library #bstpath onlinelibrary.wiley.com/doi/full/10.11…

DEK::AFF2 Fusion-Associated SCC: A Case Series with Literature Review on an Emerging & Challenging Entity SE Amin, JS Lewis Jr, JA Bridge, J-F Hang, U Naik, JA Bishop & K Saluja rdcu.be/ehACG #HeadNeckPathol #HNPJ #HeadandNeckPath #Pathology #ENTPath #PathologyTweet

2023 revised diagnostic criteria for IgG4-related ophtalmic disease Important consideration is that other non-neoplastic and neoplastic processes may have increased IgG4+ plasma cells -Idiopatic orbital inflammation -Lymphomas -Histiocytosis Dr. Vizcaino #USCAP25 #pathology

Not all squamous metaplasia is equal. When found in the bladder, always note whether keratinization is present—non-keratinizing form is more often benign, while keratinizing form raises concern for dysplasia/carcinoma and requires careful follow up. #GUPath #PathTwitter #MedEd

Yellow-purple material with a fish scale appearance, i.e. looked like Sevelamer. Patient had kidney disease, but also had a working transplant, so normal electrolytes, i.e. no reason to be on a phosphate or potassium binding resin. Was on bile acid sequestrant, colesevelam.

MIMIC of Celiac's Disease +❗️of checking med list esp if nml Celiac🧪: 💊 Olmesartan-induced Enteropathy Olmesartan 🟰 Angiotensin II receptor blocker to treat HTN Rare side effect ->enteropathy w prolonged diarrhea+ weight loss 🔬 ➡️ can show IEL+ villous atrophy #pathx

In cases presenting with spontaneous pneumothorax, hemothrorax the pleural bx/wedge which show no specific histo findingsExcept some pleural fibrosis, bloodetc. what is the importance of histopathology in such cases? How helpful will our reports be? Sanjay Mukhopadhyay your thoughts?

🦷 27 y/o F with Wisdom Tooth Extraction 🧻 Packing Done w Petroleum based Gauze 🤕 Returns 1 month later w persistent pain ⬇️ 🎨 PAS and GMS - 🤔 Dx? #pathx #pathologyx #entpath #microx #pathologytwitter

Pathologists! What do you think of this inguinal lymph node removed at the time of hernia repair in a young man? What is the CD10+ population outside follicles? Note that CD10 is stronger than in germinal centers. Hint: they are not granulocytes. #hemepath #lymphnodes

🧬 Hepatic Amyloidosis: a rare and challenging diagnosis Not every case of cholestatic jaundice with hepatomegaly is due to common liver diseases. Although systemic amyloidosis is more frequently associated with renal and cardiac involvement, isolated hepatic amyloidosis is an

Most phosphaturic mesenchymal tumors are ERG positive! ncbi.nlm.nih.gov/pubmed/28614212 (&have FGFR1 translocation ncbi.nlm.nih.gov/pubmed/26759148) #ENTpath