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Autism-linked mutations of CTTNBP2 regulate #LLPS to control synaptic protein enrichment. A #Zinc-induced liquid-to-gel transition improves synaptic retention of CTTNBP2 and SHANK3. Yi-Ping Hsueh, Kuo-Chiang Hsia, IMB Academia Sinica, Pu-Yun SHIH, Yu-Lun Fang #ASD #Synapse go.nature.com/3wpJtfp

Week of 11/17/22 - 1) What removes cilia? Dividing cells gotta do it! Miyamoto et al implicated KIF2A, a depolymerizing kinesin. sahana shankar, Jens Luders @LudersLab.bsky.social, Su-Yi Tsai, Hsia et al show γ-TuRC recruits KIF2A to basal body. How is this triggered at G2/M? sciencedirect.com/science/articl…

Α γ-tubulin complex-dependent pathway suppresses ciliogenesis by promoting cilia disassembly dlvr.it/Sd7hwk

Dr. Yi-Ping Hsueh’s team at IMB Academia Sinica used autism model mice to reveal how autism spectrum disorders exhibit a higher prevalence in males compared with females. Brain Read more: tinyurl.com/autismsexbias #autismspectrum #geneticstudies #biology

A zinc-dependent structural transition of #SOD1 modulates its ability to undergo phase separation Krishnananda Chattopadhyay Jeetain Mittal CSIR, India CSIR-IICB embopress.org/doi/10.15252/e…

1/3 So proud of ChookLab PhD student Jenny Jiou, PhD (she/her/她) for her extraordinary contributions to biorxiv.org/content/10.110… - 3 cryoEM structures including of the unusual ternary complex of Kap114 (Sc Importin-9) simultaneously bound to a cargo H2A-H2B+RanGTP. And more!

Check out our new institute website and the exciting biologies we do at IMB Academia Sinica 👉 imb.sinica.edu.tw/en/index.php

Checkout this article in Molecular Cell "Condensed-phase signaling can expand kinase specificity and respond to macromolecular crowding" by Liam Holt & others #CellBio2022 hubs.li/Q01tSW2n0

I’m so thrilled to meet Eden, a former research assistant in the lab and currently a fourth year graduate student at University of Wisconsin-Madison, at #ASCB2022. Time really flies! Feel proud of/excited about your Ph.D. research!

Some past and present members of the Kapoor lab happily reunited at #ASCB2022, including Tarun Kapoor, Radhika Subramanian, Scott Forth, Yuta Shimamoto and Kuo-Chiang Hsia.-Food, science, and friendship.

Our latest work headed by former postdoc Aamir Ali finally out - we describe cooperation of XMAP215 family microtubule polymerase ch-TOG/CKAP5 with #gammaTuRC in promoting #microtubule #nucleation in human cells. Details here: rdcu.be/c4cFp For a summary continue 1/n 👇🏼

Having Yuh Min Chook visit IMB Academia Sinica in Taipei and give a seminar is wonderful and so inspiring. It is fun to chat about fundamental questions in biology, even during the dinner time! Wei-Le Wang See-Yeun Ting 陳詩允 Kiback Lee-Jung Juan

cell.com/cell-reports/f… The first research article of TiLab is out.😃 By employing the recombinant tubulin strategy, we reveal the roles of tubulin isotypes in regulating the activities of enzymes for tubulin tyrosination and microtubule stability.

careers.cell.com/job/10655/open… The Institute of Molecular Biology (Academia Sinica, Taiwan) is recruiting young and talented faculty!