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NEWS&VIEWS | Coenraad F. Slabber & Jan S. Tchorz (Novartis) A new study highlights #spatiotemporal #metabolic reprogramming in #hepatocytes during metabolic transitions between #feeding states. nature.com/articles/s4225…

Proud to announce new work from our lab in BioRx: CES1 Deficiency is Associated with Metabolic Reprograming and Endothelial Dysfunction in Pulmonary Arterial Hypertension biorxiv.org/content/10.110…

Make that BioRx twins! LOSS OF ROR2 TYROSINE KINASE RECEPTOR IS ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION IN PAH VIA INAPPROPRIATE INTEGRIN β1 ACTIVATION biorxiv.org/content/10.110…

Calling all outstanding NP's & PA's! Come join us in Charleston for an unforgettable year as we launch one of the first cardiology fellowships of its kind with an advanced heart failure focus. Learn about patients with HFrEF/HFpEF, transplant, LVADs, hemodynamics & more!

Gut microbiota-derived extracellular vesicles exhibit diurnal regulation and activates hepatic gluconeogenesis Molecular Metabolism sciencedirect.com/science/articl…

Grateful for the opportunity to put together this review on the role of the gut microbiome & infections on PAH with my amazing colleagues Thenappan Thenappan Suellen D`Arc Oliveira Imad Al Ghouleh . Thanks to the special issue editors Navneet Dhillon Ghazwan Butrous & Dr. Oliveira. mdpi.com/2036-7449/17/3…

A mutation in oncostatin M causes severe bone marrow failure. First report linking OSM to human blood disease. Read more in JCI! By Pr. Julien Bertrand et al. Full jci.org/articles/view/… Summary unige.ch/medecine/gcir/… #Hematology #BloodDisorder #BoneMarrowFailure #OncostatinM

International BPA Registry just published in JACC Journals. ZERO in-hospital mortality during 2327 procedures in 18 expert centers worldwide! Reduction of PVR - 57%, reduction of mPAP -38%. Happy to be a part of it! jacc.org/doi/10.1016/j.… Polskie Towarzystwo Kardiologiczne International CTEPH Association Polskie Towarzystwo Chorób Płuc

Original Article by S. Shekar et al.: People Overtrust AI-Generated Medical Advice despite Low Accuracy nejm.ai/43xKDG0 #AIinMedicine

Big news at MUSC! The MUSC College of Medicine has received a historic $50 million anonymous donation, the largest single gift in MUSC’s 200-year history. Together, we’re building a healthier future and #ChangingWhatsPossible for our state. Learn more: musc.co/43ZNKpi

Nice editorial from Drs. Hemnes and Rischarge on Sasha Prisco, MD, PhD's latest paper highlighting areas for future research for the microbiome in RV inflammation and dysfunction. Thanks for sharing their thoughts! ahajournals.org/doi/10.1161/CI…

RESEARCH | Z Ying, X Liu et al. (Guangzhou Medical University): The mitochondrial unfolded protein response is shown to inhibit #pluripotency during somatic cell #reprogramming. 🧫✨ nature.com/articles/s4225…

Sex, drugs, and microtubules? Wonderful collaboration with the Gardner laboratory to demonstrate estrogen directly modulates microtubule dynamics via a tip interaction similar to colchicine. nature.com/articles/s4200…. 3CPR Council The Pulmonary Vascular Research Institute AHA Science.

NEWS&VIEWS | M Bartez, D Chen (UC Berkeley): The mitochondrial unfolded protein response controls the mesenchymal-to-epithelial transition during the acquisition of #pluripotency. 🧫✨ nature.com/articles/s4225…

Our latest review on Anti-remodeling therapies in pulmonary arterial hypertension: Trends in Pharmacological Sciences cell.com/trends/pharmac… 3CPR Council ATS PC Assembly The Pulmonary Vascular Research Institute IUCPQ-ULaval

Hepatic micropeptide modulates mitochondrial RNA processing machinery in hepatocellular carcinoma dlvr.it/TLSgtF

Our latest paper, Identification of conserved and tissue-restricted transcriptional profiles for lipid associated macrophages, is online at Communications Biology. UMN Integrative Biology & Physiology Ivanov lab Xavier Revelo rdcu.be/esUdT

nature.com/articles/s4156… excellent article by Dunja Aksentijevic Ricciarelli and Christoph Maack reviewing mechano-energetic uncoupling, how it goes wrong in heart failure, and clinical translation of the science. Thorough, I will be referring back to this a lot!

Great for Thenappan Thenappan to get his phase 1 trial evaluating microbiota transplant accepted today! Proud to play a small part in this cool study.

medicine.washu.edu/news/strategy-… Great collaborative effort with Apte Lab WashU Medicine WashU Medicine Cardiovascular Division Zhen Guo identifying a new role for ApoM in macular degeneration