We are proud to present our small contribution to the global efforts on #COVID19 research: our results indicate that #epigenetic #ageing is not accelerated in patients infected by #SARSCoV2. Check our new preprint here: medrxiv.org/content/10.110…

In our latest publication we investigated if #DNAmethylation changes during in vitro cell culture are caused by epigenetic drift. Check out our new #epigenetics paper in Communications Biology nature.com/articles/s4200…

We are looking for Ph.D. candidates to work on (1) bioinformatics for multi-modal single cell/spatial omics on kidney disease with Christoph Kuppe and (2) impact of age related DNA methylation on gene regulation with Stemcellbiology Aachen . Details tinyurl.com/a9x47pjp . Please RT

DNMT3A knockouts in human iPSCs prevent de novo DNA methylation and reveal growth advantage during hematopoietic differentiation biorxiv.org/content/10.110…

Please check our new Biomaterials article. Congratulations Mohamed :) doi.org/10.1016/j.biom…

Imagine leukocyte counts with a simple finger prick. #EpiBloodCount can provide standardized analysis of leukocyte subsets from dried or frozen blood. academic.oup.com/clinchem/advan…

A brief review on how to translate DNA methylation biomarkers into clinical practice. doi.org/10.3389/fcell.…

Between murine mouse strains the methylome and age-associated DNA methylation may differ almost as much as between wild type individuals. biorxiv.org/cgi/content/sh…

Our new study on age-associated DNA methylation in mice was just published. There are marked differences between mouse strains. frontiersin.org/articles/10.33…

Hematopoietic differentiation remains possible in iPSC with #DNMT3A knockouts. We collected this data for more than 4 years and we are glad to now see it published at BMC Biology. Congratulations to Olivia and everybody involved. bmcbiol.biomedcentral.com/articles/10.11…

If you are interested YAP, please have a look at our preprint. biorxiv.org/cgi/content/sh…

Are your iPSC realy pluripotent? GermLayerTracker is a new biomarker to track differentiation toward endoderm, mesoderm, and ectoderm. This work was driven by three fantastic PhD students. cell.com/stem-cell-repo…

We have an open PhD position on epigenetics in leukemia (myeloproliferative neoplasms). It rocks - please share @MPN StemCells Leukemia E3 Engaging Epigenetics Experts ukaachen.de/fuer-bewerber/…

YAP! It is essential! It is a pleasure to share this work of Kira and coworkers demonstrating that YAP1 is essential for self-organized differentiation of pluripotent stem cells. doi.org/10.1016/j.bioa…

This week, our Institute for Stem Cell Biology had a Lab-Retreat in Trier. We had very stimulating discussions about science and future perspectives for research and lab-organization. IT REALLY IS A PRIVILEGE TO WORK WITH SUCH A FANTASTIC TEAM!!!

Proud to share this new preprint on cellular aging in myeloproliferative neoplasms. Our results indicate that cellular aging is accelerated in malignant MPN clones and this can provide a target for treatment with senolytic drugs or telomerase inhibitors. medrxiv.org/content/10.110…

Substrate elasticity impacts differentiation and the epigenetics of iPSCs? It does apparent not... biorxiv.org/content/10.110…

Cancer shapes it microenvironment. Cancer associated fibroblasts #CAF become activated and reprogrammed and this is even reflected in their epigenome. We observed very similar changes in their DNA methylation pattern across different types of cancer. biorxiv.org/content/10.110…

There is a network between epigenetic clock sites! I am happy to share this preprint on our recent study: doi.org/10.1101/2024.0…

Aging is more than just a line. Instead of multivariate models epigenetic clocks can also be trained as a probablistic model on 2D-kernel density estimation: doi.org/10.1101/2024.0…