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Thrilled to present our collaboration w/ Stergachis Lab members “The regulatory potential of transposable elements in maize”. Single-molecule Fiber-seq - accurate and sensitive accessibility in maize. New open chromatin regions in LTRs and much more! biorxiv.org/cgi/content/sh…

Our latest, from the brilliant Will Chen and Junhong Choi, out in nature , is ENGRAM, a multiplex method for symbolic recording of signaling and cis regulatory activity to DNA. Final version (not in preprint) includes integration w/ DNA Typewriter. rdcu.be/dN62L

Good news/bad news paper of the day. A fungi that degrades plastic waste😃...into CO2 🥲sciencedirect.com/science/articl…

This recently published figure by Sarah Ancheta et al. is very disturbing and should lead to some deep introspection in the single-cell genomics community (I doubt it will). It demonstrates complete disagreement among 5 widely used "RNA velocity" methods 1/

Thrilled to share that our latest work in the Christodoulou lab is now published in Nature! nature.com/articles/s4158… Thanks to everyone who contributed Ivana Bukvin, Sammy Chan, Tomek Wlodarski, Angelo M Figueiredo , Chris Waudby 🦋, Lisa Cabrita, Anais Cassaignau, John Christodoulou!

Today out in bioRxiv we present SCOPE. An optics-free, self-registering array of DNA encoded beads for spatial genomics. This was work led by the intrepid duo of Hanna Liao and Sanjay Kottapalli, with Jay Shendure's lab. biorxiv.org/content/10.110…

Somehow 4 optics free spatial imaging papers hit BiorXiv today. It's like watching the olympics of paper submission. May the fastest editor win!

Happy to share our paper 'Predicting Conformational Ensembles of Intrinsically Disordered Proteins: From Molecular Dynamics to Machine Learning' just published in @jphyschem Letters. Excellent work by J Aupic, Pavlína Pokorná Sharon Ruthstein read here: pubs.acs.org/doi/10.1021/ac…

10,000 wine yeast strains were evolved in the lab, with scientists selecting for variants that could tolerate high alcohol levels or produce lots of aroma—while dividing quickly. Biotech-inspired wine and beer is an underrated market. Now is probably a good time to work on it.

Nick Desnoyer One movie of anther opening in A. thaliana 😉 Captured by spinning-disk microscope.

There is a new tool on BioIcons to turn any protein (in PDB format) into a 2D vector illustration in SVG format. You can upload any PDB file or import from PDB, AlphaFoldDB or ESMFoldDB. Feedback welcome :) bioicons.com/pdb2vector/

Dear Google Maps, please add a feature that maximizes a walking path for tree density, aka shade, and not time or distance. This would be great for anyone in a new city!

parents please check your kids' halloween candy. just found hieronymus bosch’s garden of earthly delights inside of a peanut butter cup.

Free scientific illustrations for biologists! 😍 NIH has released a library of 500+ free scientific illustrations to create figures, presentations, and illustrations! all freely available in the public domain. Retweet and spread the message! bioart.niaid.nih.gov

Fluorescent labeling of proteins in vitro and in vivo using encoded peptide tags sciencedirect.com/science/articl…

You may ask: “why study ancient enzymes? Who cares what life looked like 3 billion years ago?” Because evolution may hold answers to problems we still struggle with, and it can guide our efforts. New paper from our lab! 🧵

Want to make a plea to science journalists as well to be EXTREMELY skeptical of big claims from AI4bio models. Present balanced view points & wait for the "dust to settle" before over amplifying premature hype. Billions of parameters & data points alone will not solve biology.

The paper clarifies that most so‑called “inverse‑folding” models (ProteinMPNN, ESM‑IF) actually perform structure‑based sequence design and do not guarantee the target fold is the unique low‑energy state, leaving the true inverse‑folding problem wide open

We don’t have a health department anymore—just podcast bros and wellness gurus.