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🚨NEW REVIEW🚨The flexibility of disordered proteins makes them ideal sensors of the cellular environment. Read how this happens and why YOU should care in this review! With dream team David Moses , Garrett Ginell, and Alex Holehouse. shorturl.at/diqY8 (Open access)

Excited to have our latest work out today in Cell, an incredible collaboration between Cigall Kadoch @Kadochlab @Brangwynnelab Amy Strom Ajinkya Patil. We dissect the many roles of ARID1A in BAF complex function! cell.com/cell/fulltext/…

The final version of our review, "How it feels in a cell" is out in Trends Cell Biology. Led by @bonucci_martina and Tong Shu. doi.org/10.1016/j.tcb.…

Love #IDRs? 🍝 Our new work explores the link between IDR sequence, ensemble, and function - all measured in live cells using rationally designed IDRs! biorxiv.org/content/10.110… Our IDR design tool (GOOSE) is available on GitHub & as a colab notebook tinyurl.com/idrdesign

Myospreader improves gene editing in skeletal muscle by myonuclear propagation biorxiv.org/cgi/content/sh… #bioRxiv

💪🚀💪 Congrats!! Eric T Wang Kiril Poukalov

I can’t recommend this course highly enough. It’s a cross between intensive astronaut training and summer camp, but for cell biology. Amy and Cliff will make outstanding directors!

this in undoubtedly true… got derailed for months earlier this year by an antibody with plenty of publications that recognized a different protein that happened to be the same exact size as my protein… wasn’t the first time either… protein design folks plz save us!

Now published! nature.com/articles/s4159… Big congrats to Jeff, Garrett, and Dan! Predict your IDR's radius of gyration or end-to-end distance at metapredict.net or predict all IDRs & their dimensions + properties at proteome-scale in seconds here colab.research.google.com/github/holehou…

This is how I live my life

NYC in the snow is a time portal to another dimension… always hoping this won’t be the last time!

This is a very cool paper and (potentially) highlights similar mechanistic pathways underlying cell-cell fusion in multiple human syncytia (placenta, bone, skeletal muscle):

Had an awesome time giving a Night Science chalk talk yesterday with Peter H Whitney… thanks Itai Yanai for putting this series together and all our friends at NYU for the discussion. Highly recommend this open brainstorm/whiteboard format.. a great addition to traditional seminars!

Lance Denes Peter H Whitney You guys were amazing! It was such an inspiring night science session. Now I’m looking forward to next month’s session with Arjun Raj!

Perhaps worth pointing out that virtually all science to date has been communicating using 2D visualizations called "papers". So it is possible for 2D visualizations to have at least some meaning :).

galaxy brain gpt for image analysis is cut out the middle man and skip the code entirely… how do we write this into a methods section?

Super interesting use of GEMs!

UMAP

this is the only way I make genomic PCR primers now and has never failed