New publication spearheaded by former PhD student Stefan Butz published today. Systematic dissection of DNA sequence and chromatin regulators involved in maintenance of epigenetic memory at imprinted control genes. nature.com/articles/s4158…

1/6 Very excited to announce sciMETv2 for high-throughput robust single-cell DNA methylation analysis led by Ruth V. Nichols & Brendan L. O'Connell out in Nature Communications! #SingleCell OHSU Brain Institute OHSU Knight Cancer Institute OHSU News OHSU School of Medicine #epigenetics rdcu.be/c1kdp

Today we report in Nature Biotechnology evolved TadA-assisted N6-methyladenosine sequencing (eTAM-seq), an enzyme-assisted sequencing technology that detects and quantifies m6A by global adenosine deamination. nature.com/articles/s4158… 1/n

A DNA methylation atlas of normal human cell types Very proud of my colleagues at the Hebrew University faculty of medicine for an amazing publication in Nature. This is supposed to be a major leap forward for liquid biopsy. nature.com/articles/s4158…

Thrilled that our Spatial ATAC manuscript is now out Nature Biotechnology  Open: nature.com/articles/s4158… We repurposed the #Visium platform 10x Genomics to capture and profile open chromatin with spatial resolution in tissue sections from mouse and human.

Simultaneous sequencing of genetic and epigenetic bases in DNA go.nature.com/3YkrCle

Now online! Transgenerational inheritance of acquired epigenetic signatures at CpG islands in mice dlvr.it/Sj58rx

Happy to announce that our story on #DNAmethylation at #enhancers is out today in Molecular Cell! tinyurl.com/smc5yccy It was a fantastic PhD journey in the lab of @arnaud_kr @EMBL. Follow the 🧵 to find out whether #DNAmethylation is important for enhancer activity: (1/9)

Very excited to share a review on single cell proteomics enabled by next generation sequencing or mass spectrometry. This was a fantastic collaboration between NGS and Proteomics groups within our larger department @Genentech. Check it out and pass along! nature.com/articles/s4159…

Spatial epigenome–transcriptome co-sequencing🤩🤩🤩Beyond excited to see it out today nature! Enjoyable collaboration between my lab @YaleBME @YaleSEAS Yale School of Medicine and GonçaloCasteloBranco of Karolinska Institutet. The most informative tool for spatial multi-omics!! nature.com/articles/s4158…

Many congratulations to Nada Jabado Claudia Kleinman @selinjessa @CarolCLChen and colleagues for spectacular paper on H3.3G mutations in Cell cell.com/cell/fulltext/…

Thrilled to share our latest work from Joe Ecker lab, using cutting-edge snmC-seq3 and snm3C-seq technologies to generate 301,626 methylomes and 176,003 mC+3C multiome profiles from 117 dissected regions throughout the adult mouse brain. (1/n) biorxiv.org/content/10.110…

If you're into retrotransposon regulation, particularly LINE-1 DNA methylation, check out our latest preprint: biorxiv.org/content/10.110… #TE #transposon #epigenetics #methylation kudo to @sophie_lanciano David Pratella @Orel_Doucet, our collaborator Pierre Defossez & all other authors 👇

Loving this EpiGenie feature on our new DM-Seq method for direct enzymatic sequencing of 5-methylcytosine..."a DM you'll want to slide into." We agree! Slide on over to the link below 🛝👇. And then go #RunDMSeq🧬! epigenie.com/dm-seq-a-dm-yo…

Mammalian Methylation Consortium unveils key findings: 1) Phylo-epigenetic trees, built on ultra-conserved cytosines, align with known phylogenetic trees - showing evolutionary pressures on epigenetics. 2) Methylation patterns linked to max life span differ from those tied to

Excited to share our new review exploring brain insulin's ability to moderate the effects of early life adversity available now in @ELSneuroscience Neuroscience & Biobehavioral Reviews Patricia P. Silveira McGill University McGill Psychiatry Douglas Research Centre Ludmer Centre authors.elsevier.com/sd/article/S01…

In 21 papers across Science, Science Advances, and Science Translational Medicine, researchers with the #BICCN consortium present an atlas of the human and nonhuman primate brain in unprecedented detail. The results uncover the genetic organization of the human brain. scim.ag/4ro

Molecular mechanisms of transgenerational epigenetic inheritance go.nature.com/40mNtL0 #Review by Maximilian H. Fitz-James & @giacomo_cavalli CNRS 🌍 Université de Montpellier InstituteHumGenetics

BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

scDotPlot Cluster a Single-cell RNA-seq Dot Plot bioconductor.org/packages/relea… 🧬🖥️🧪