
The Leeboratory
@leeboratory
Investigating Mechanisms Controlling Cell Identity
ID: 1238864341962829830
https://www.maxperutzlabs.ac.at/research/research-groups/leeb 14-03-2020 16:27:37
84 Tweet
270 Followers
330 Following


Tissue-intrinsic #betacatenin signals antagonize #Nodal -driven anterior visceral #endoderm differentiation | @NatureCommunications Christian Schroeter, nature.com/articles/s4146…

2️⃣ new publications from Joao Matos and his team with are out now! 🤩 In Cell Press the team introduces a new method for investigating filaments. In Developmental Cell the team characterizes the proteome during meiosis 🧬 ➡️ tinyurl.com/rmv29yzv and tinyurl.com/2b39nf3m



Latest in our Plasticity Project, featuring our fave cells, Primitive Endoderm (PrE), and their in vitro model, nEnd. Amazing PhD journey @MLAgerhom, contributors AnnikaCharlotte alboo Marta Perera Martin Proks Teresa Knudsen Manzanares lab (1/11). twtr.to/FfAst

🚨 Paper Alert! A hallmark of Parkinson's is deficiency in mitophagy ⚡️ Elias Adriaenssens, post-doc with @martens_sascha, lightens the molecular mechanisms behind mitophagy initiation 🔍 The study is published in NatureStructMolBiol ➡️ tinyurl.com/3449dhrs Universität Wien MedUni Wien




I’m thrilled to finally see the main project of my PhD in the The Leeboratory out in #NatComms. Congrats to all authors and collaborator Nicolas Rivron ! We identified FoxO transcription factors as crucial AKTors in the naïve to formative pluripotency transition. rdcu.be/dTqVm

Another great piece of science from Laura Santini! We identified nuclear translocation of FoxO transcription factors as crucial event in the transition to formative pluripotency. Great thread below.

Great science by Laura Santini . Great and funny artwork by @LuisMiguel2890 . Great teamwork by the Leeboratory !

🔬 Dr. Laura Santini (Laura Santini) and scientists at Universität Wien demonstrated that phosphorylated AKT acted as a 🚧 gatekeeper that prevented nuclear localization of FoxO transcription factors in naïve ESCs. Nature Communications | go.nature.com/3XB4XU1


After a massive team effort leaded by the incomparable Nicola Festuccia I am really happy to share our freshly published Science Magazine ms where we elevate Nr5a2 to the top of gene regulation in the morula. 🔥🔥🔥 Take a look at Nicola's description 👇! science.org/doi/10.1126/sc…







We are happy to contribute to this exemplary collaborative study aimed at improving the efficiency of working with human naïve ESCs without MEF feeder cells. It is a pleasure to work with GrazianoMartello, Jan Żylicz, @vincentpasque , and Nicolas Rivron