Review Annual Reviews Carrie Lucas Mackenzie J Bender Decoding Immunobiology Through Genetic Errors of Immunity annualreviews.org/content/journa…

Fantastic effort by Lena Wirth and the whole team (Georgetown Lombardi Dana-Farber News Hoosier Cancer + many others) to understand some key (and targetable?) determinants of anti-PD-1 response/resistance in RCC Cancer Discovery Yale Cancer Center Yale Urology Yale Pathology Yale School of Medicine Yale Department of Immunobiology

TLS and T-Cell Exhaustion Drive PD-1 Blockade Responce in RCC - Lena Wirth (Lena Wirth) Cancer Discovery oncodaily.com/science/247696 #OncoDaily #Oncology #Cancer #Health #Medicine #MedTwitter #MedEd #MedOnc #MedNews

Out today in Nature Cancer: after neoadjuv cabo, ⏫T cell activation & immune niche formation in pts with advanced RCC. + truly delighted to have been a part of this exciting study from Haydn Kissick, Mehmet Asim Bilen,MD, and Viraj Master and many other friends back at Winship Cancer Institute of Emory University!

A comprehensive study of effective + resistant responses to a #kidneycancer anti-PD-1 therapy found specific immune features that could provide new targets to improve #cancer treatment, according to research from the Braun Lab David Braun, Lena Wirth, et. al.

If you’re interested in how monogenic diseases can lead to insights on human immunobiology, check out this review I wrote with Carrie Lucas ! annualreviews.org/content/journa…

We report a new role for HIF in the regulation of endogenous retroviruses! It was a big collaborative effort to explore the HIF-mediated transcription, expression, and HLA presentation of ERVs in kidney cancer and leveraging them for immunotherapy cell.com/cell/fulltext/…

Is there anything more fun than starting your talk with a walk-up song?! Thank you to the brilliant 3rd year Immunobiology PhD students at Yale who organized the '12th Yale Immunobiology Student Symposium' today.

Review led by superstar heme/onc fellow Zak Yochum Yale Hematology Oncology Fellows

Thank you so much to the organizers of #AAI2025 for selecting me as a recipient of the AAI Thermo-Fisher Trainee Achievement Award! And I’m not complaining that I got to receive it in the beautiful state of Hawaii 🌺 (1/2) The American Association of Immunologists (AAI)

If you’re here and interested in hearing about how we are utilizing an interactive board game to convey meaningful immunological interactions to the public, come to my talk on Tuesday at 9:45-10am room 319!

From the May issue: 'Presence of Tertiary Lymphoid Structures and Exhausted Tissue-Resident T Cells Determines Clinical Response to PD-1 Blockade in RCC brnw.ch/21wSSDz By Miya Hugaboom, Lena Wirth, Kelly Street, Neil Ruthen, Michael Atkins, Catherine Wu, David Braun

I discuss the urgent crisis from the loss of federal support of science in the US and recent clinical gene editing breakthroughs with Walter Isaacson & Christiane Amanpour on Amanpour and Company, airing on PBS tonight at 11 pm ET, and on CNN International earlier today. Pls share! youtube.com/watch?v=8YhJM6…

Great work from Chris Labaki BIDMC , led with Eddy Saad and #KatrineMadsen. Large team effort led together with Lisa Henske Brigham and Women's Hospital Sachet Ashok Shukla MD Anderson Cancer Center and Eli Van Allen and Toni Choueiri, MD Dana-Farber KidneyCAN Kidney Cancer COA - Chromophobe and Oncocytic Tumor Alliance OncLive.com

Some of my favorite (non exhaustive list) people presenting their work at #KCRS25 - a thread You can find the poster and e-poster abstracts online, some hidden gems there OncoAlert

A TGF-βR/IL-2R immunomodulatory fusion protein transforms immunosuppression into T cell activation to enhance adoptive T cell therapy Yapeng Su @FredHutch 🇺🇸 pnas.org/doi/10.1073/pn…