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Myelin debris as an initiator of microglial dysfunction and neuropathology in Alzheimer’s disease nature.com/articles/s4142…

1/n Our multi-ancestry #GWAS meta-analysis of major depression is now published in Cell. cell.com/cell/fulltext/… A thread 🧵:

🧠 Women are twice as likely to develop Alzheimer’s disease. Many factors may contribute. Our lab is focused on understanding contributions from vasculature! science.org/stoken/author-… (1/7)

This pretty much settles it: we're entering the era of low-cost, on-demand binders for everything Excited to see what people build now that "inject a llama with some junk and bleed it a month later" is no longer the cutting-edge tech nature.com/articles/s4158…

Parental origin of transgene modulates amyloid-β plaque burden in the 5xFAD mouse model of Alzheimer’s disease: Neuron cell.com/neuron/fulltex…

Are you using 5xFAD mice to study Alzheimer’s disease? Our work Neuron may be relevant to you 🐁 Age and sex are known to influence Aβ plaque burden in these mice. Here, we found that the transgene parentage is another strong determinant. (1/11) cell.com/neuron/fulltex…

Tetanus on demand! (not for bioweapons, but for neuroscience research) Tetanus toxin induces paralysis by using a protease to cleave VAMP2, a protein required for synaptic vesicle fusion and neurotransmitter release. To harness this toxicity and use it as a beneficial tool for

What are 26 different Rab GTPases doing on Lipid Droplets? Are lipids transferred by membrane contact sites? Moving the FAT: Emerging roles of Rab GTPases in the regulation of lipid droplet contact sites by Mariano Alonso @albertpol10 and Harriet P Lo sciencedirect.com/science/articl…

New TYP lab publication out today in Glia, led by talented previous PhD student Hyo Lee! Our first big analysis of induced Astrocytes from 44 individuals in the ROSMAP cohort. You can find it here: onlinelibrary.wiley.com/doi/10.1002/gl…

Is making brain HDL by inducing ABCA1 a viable strategy for APOE4 Alzheimer's? Our talented researcher Dr. Shaowei Wang has looked deeply into this question over the past 6 years, and the work has finally been published 5/5:

A man was destined for early Alzheimer’s ― these genes might explain his escape nature.com/articles/d4158…

No words.

On Valentine’s day, 15 Assistant Professors at NIH who had started their research labs in the last 2 years were fired. Their scientific expertise was built over 10-12 years of training, most if not all of which was supported by NIH.  The start up funds for their laboratories were

I found out this morning that my NIH NICHD News F31 fellowship to study the biomechanics of uterine fibroids was CANCELLED.

My F31 is gone. It’s a small loss in the scheme of things but I was really proud of it.

Excited to share our paper on the Connectome based predictive modeling in individuals with Autosomal Dominant AD with amazing collaborators Yakeel T. Quiroz, PhD (she/her), David Somers,Josh Fox-Fuller, Ph.D. and team! alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Exciting postdoc positions available! Join in applying iPSC-derived human brain tissue to dissect and therapeutically target the root causes of neurodegeneration. @sinaiBrain, Mount Sinai Stem Cell Competitive salary and Subsidized housing provided. Please retweet!

The university will not surrender its independence or relinquish its constitutional rights. Neither Harvard nor any other private university can allow itself to be taken over by the federal government. hrvd.me/ResearchFundin…

What is the role of myelin in Alzheimer's disease? Excited to share our new Perspective in Nature Cell Biology, where we review the role of oligos and myelination in AD, with Anna Bright, Joel W. Blanchard and Li-Huei Tsai. nature.com/articles/s4155…

Last month, I defended my PhD! My thesis was about how the Alzheimer's disease risk gene APOE affects oligodendrocytes, myelin, and lipid metabolism. I am so grateful to all my mentors (especially Li-Huei!), friends and family! 💛🧠