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プレプリントアップデートのお知らせをします。改めて仕切り直しました。とはいえ、前バージョンを大幅に改訂しましたのでほとんど新しい論文となっています。

We are excited to report the discovery of TIGRs, a widely-occurring RNA-guided system found in bacteria and their viruses. TIGRs consist of a peculiar repeat region which is transcribed into RNA and processed into multiple guide RNAs to direct TIGR-associated proteins to their

I am beyond excited to present my postdoc work to the community. I have synopsis of this paper on the bluesky account (or enjoy the preprint below).. #cellmigration #cancer #blebs 🦋 account ankita13jha.bsky.social biorxiv.org/content/10.110…

🧠Recently published in Bioinformatics Advances: "A Kolmogorov metric embedding for live cell microscopy signaling patterns"    Read more here: doi.org/10.1093/bioadv… Authors include: Layton Aho  Paolo Armando Gagliardi

Can only recommend! Allows you to approach microfab like 3D printing - any design can just be prototyped within a couple hours. Game changer for our lab. x.com/lhinderling/st…

Are you using phospho-ERK staining to infer Ras/MAPK signaling history of fixed cells? Check out our recent work demonstrating how this can be misleading, and how to get more spatio-temporal information out of immunofluorescence staining. nature.com/articles/s4146…

Hi bio+ML folks! Check out our recent work modeling live-cell microscopy data with fixed-cell protein measurements. Here are cells expressing a biosensor of an enzyme, followed by multiplexed immunofluorescence staining of several proteins in the same cells. Biology+AI Daily

Superb article from Abhineet Ram and John Albeck demonstrating that single-cell ERK history can be reconstructed by end-point measurements!

Don't miss the first Smart Microscopy Days on YouTube! 🔬 📅 June 16th & 17th ▶️ Hosted on RTmfm’s YouTube channel Organised by the IBDM (Marseille FBI's node) and MFM_Microscopy, these days aim to raise awareness and provide training on intelligent imaging acquisition tools

Excited to join the first-ever Smart Microscopy Days, powered by IBDM & France-BioImaging! Catch INSCOPER’s Rémy Torro live in Marseille & on YouTube, June 16–17. #SmartMicroscopy #ImagingInnovation #INSCOPER #LifeSciences #FranceBioImaging

One protein, two opposing roles: This ‘compelling’ study shows how the same signalling molecule can drive either protrusion or retraction in migrating cells depending on its concentration and activation dynamics. elifesciences.org/articles/93180…

One protein, two opposing roles: This ‘compelling’ study shows how the same signalling molecule can drive either protrusion or retraction in migrating cells depending on its concentration and activation dynamics. elifesciences.org/articles/93180…

Joe Tyler joe, Anthony Davidson, Vassilis Koronakis & team find that inhibition of PAK activity leads to the production of PI(3,4,5)P3 at the plasma membrane & a dysregulation of the actin cytoskeleton. journals.biologists.com/jcs/article/13… Article: journals.biologists.com/jcs/article/13… #OpenAccess

Have you ever thought about inflating tissues? Or maybe quickly deflating those inflated tissues? New #EpithelialMechanics pre-print: doi.org/10.1101/2025.0… 🧵with pressure control, multiscale buckling, patterned wrinkling