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Congrats to Adam Fenton (Holzbaur & Jongens labs) on his recent publication "PGC-1α integrates insulin signaling with mitochondrial physiology and behavior in a Drosophila model of Fragile X Syndrome" nature.com/articles/s4432…

Dou, Aiken & Erika Holzbaur-Howland Penn Medicine show that #Parkinsons disease-associated hyperactive LRRK2 decreases the trafficking of synaptic vesicle proteins within neurons by disrupting the regulation of the synaptic vesicle precursor protein RAB3A. hubs.la/Q02qgtts0

Now out at PNAS - excited to share our work on how ESCRTs protect lysosomes from stress-induced membrane rupture, enhancing lysosomal resilience. Congrats to Wei Chen & team! #Lysosome #UMichBiolChem #CellBiology #researchpaper pnas.org/doi/pdf/10.107…

Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes | PNAS pnas.org/doi/10.1073/pn…

What happens when neuronal mitochondria are damaged? Our group identifies a novel Mitophagic Stress Response (MitoSR) pathway that accelerates removal of damaged mitochondria via the PINK1/Parkin mechanism. Work funded by ASAP is now online at biorxiv at biorxiv.org/content/10.110…

Our new paper is out! 📝 We identified severe lysosomal damage in the SI model of retinal degeneration and found that UA is able to boost their upcycling via lysophagy, restoring autophagic flux and alleviating vision loss 🔬👁️ …arneurodegeneration.biomedcentral.com/articles/10.11… Patricia Boya CIB Margarita Salas (CSIC)

Proximity labeling reveals dynamic changes in the SQSTM1 protein network biorxiv.org/content/10.110…

Outstanding scientists elected to EMBO Membership: in EMBO’s 60th anniversary year, 100 new members and 20 associate members join the community embo.org/press-releases…

Longitudinal autophagy profiling of the mammalian brain reveals sustained mitophagy throughout healthy aging | The EMBO Journal embopress.org/doi/full/10.10…

New work from Charlie Bond & @Melike_Lak et al offers multiplexed DNA-PAINT super-resolution pipeline for investigating #organelle heterogeneity with single organelle resolution, identifying up to 8 subsets of late #endosomes/#lysosomes in a single cell hubs.la/Q02WCK_P0

Excited to share my postdoc work, "Autophagic stress activates distinct compensatory secretory pathways in neurons" Now on BioRxiv! biorxiv.org/content/10.110…

Integrative pathway analysis across humans and 3D cellular models identifies the p38 MAPK-MK2 axis as a therapeutic target for Alzheimer’s disease: cell.com/neuron/abstrac…

FAM43A coordinates mtDNA replication and mitochondrial biogenesis in response to mtDNA depletion rupress.org/jcb/article-ab…

Small heat shock protein HSPB8 interacts with a pre-fibrillar TDP43 low complexity domain species to delay fibril formation biorxiv.org/content/10.110… #biorxiv_biophys

BioChatter is an open-source Python framework for deploying large language models in biomedical research, in line with open science principles go.nature.com/4h6FokW rdcu.be/d76rs

📢New Actin Probe Available at Spirochrome! Introducing SPY650-FastAct_X - our latest actin probe with highly improved kinetics and no toxicity! Unlike traditional probes, the newly engineered F-actin ligand does not induce F-actin stabilization. Thanks to its fast exchange on

Science is alchemy. It literally makes gold. Government investment in NIH turns $1 into $2.46 fiercebiotech.com/research/repor…

Liberty has promoted senior analyst Teddy Gallagher to OLB coach, a source tells 247Sports/CBS Sports College Football 🏈. Gallagher, 27, will be one of the youngest on-field coaches in the FBS. It’s been a fast rise for Gallagher, who was a GA at Coastal Carolina in 2022. Gallagher was a

Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer’s disease nature.com/articles/s4155…