Absolutely thrilled for work from our teams out today as part of #PsychENCODE package: science.org/toc/science/38… Grateful to play a part of this collaborative effort to investigate the basis of neuropsychiatric conditions by studying human brains at cellular and molecular levels

Tyrosine hydroxylase and Tau in the human locus coeuruleus. Image credit to LC enthusiast research assistant (and soon to be Hopkins Neuroscience grad student!!!) Heena Divecha 🔵🔬🧠😍 #FluorescenceFriday

🤩Excited to share a collaboration with Lieber Institute now appears in Science Magazine. 🙏Kudos to lead author Louise Huuki-Myers, Sr authors 🇲🇽 Leonardo Collado-Torres, Kristen R Maynard, and the whole team! 😃it's humbling and rewarding experience, fueling my ongoing method dev projects and NHGRI K99 app

🎉 Thrilled to share our latest method, IRIS, now published in Nature Methods！IRIS is a robust statistical and computational method designed to decode the spatial organization of tissues. It efficiently detects biologically interpretable spatial domains across multi-samples.

I'm very excited to share my first postdoc preprint with Boyi Guo 郭博逸 and Stephanie Hicks, PhD! Here we preset SpotSweeper - the first spatially-aware quality control methods developed for spatial transcriptomics. 🧵 biorxiv.org/content/10.110…

🚨preprint & career milestone🚨 My 1️⃣ SENIOR-author manuscript, led by 🌟🧑‍🔬Michael Totty - 🧹SpotSweeper🧹 We introduce novel spatially-aware QC for #SRT, including the popular 10x Genomics #Visium. 👇Tweetorial👇 P.S.: 🤔wonder why we named SpotSweeper

Excited to share that my undergrad work is now out in Genome Biology!

huge momentum for mRNA personalized cancer vaccines, with clinical trials ongoing for most cancers after decades of setback & improper use against metastatic disease, now technology, science, funding & trust are coming together to unlock their potential nature.com/articles/d4158…

End of summer in the Swiss Alps 🇨🇭

Exciting opportunity! I am hiring a postdoc to join the group and to develop computational methods for the analysis of biomedical data including imaging and genomics data at a single-cell or spatial resolution 🧬 stephaniehicks.com/join

We are thrilled to announce two open rank faculty searches U of Utah Human Genetics: a broad search for all areas of genetics research (utah.peopleadmin.com/postings/170913) & one focused on computational genomics faculty (utah.peopleadmin.com/postings/170449). This launches a multi-year recruiting initiative! (1/4)

Stephanie’s group is hiring! This is a fantastic opportunity for getting postdoc training. Check it out~

Fascinating week of Nobel Prizes related to computational biology and machine learning 🙂 nobelprize.org

🚨 New paper published in Nature Methods! We introduce SpotSweeper, the first spatially-aware QC methods for spatial transcriptomics. 💻 Code: github.com/MicTott/SpotSw… 📈 Website: mictott.github.io/SpotSweeper/ 📰 Paper : nature.com/articles/s4159… 🧵👇

Very excited to see this important work out led by the talented Michael Totty Boyi Guo 郭博逸 jhubiostat!

🤔Could quality control create more harm than good? We explore this question in the context of #SRT. SpotSweeper is here to combat implicit selection bias. Led by rising star Michael Totty and mentor Stephanie Hicks, PhD Tweetorial: x.com/MicTott/status…

my work with Stephanie Hicks, PhD and Boyi Guo 郭博逸 has been published in Biostatistics! tldr: the mean-variance bias exists in SRT data & impacts SVG detection. we propose #spoon, available on Bioconductor, to address this! pmc.ncbi.nlm.nih.gov/articles/PMC12… 🤩

Happy to introduce AlphaGenome, Google DeepMind's new AI model for genomics. AlphaGenome offers a comprehensive view of the human non-coding genome by predicting the impact of DNA variations. It will deepen our understanding of disease biology and open new avenues of research.

This a really exciting leap forward for genomic sequence to activity gene regulation models. It is a genuine improvement over pretty much all SOTA models spanning a wide range of regulatory, transcriptional and post-transcriptional processes. 1/

so excited to share that our preprint characterizing the dorsal anterior cingulate cortex in post-mortem human brain from Lieber Institute is out! we integrated matched SRT and snRNA-seq data to investigate agranularity and von Economo neurons