Excited to share my Ph.D. work in Carl June lab showing uninhibited CD28 co-stimulation via CTLA4 disruption invigorates dysfunctional CART cells doi.org/10.1016/j.immu…

Exciting news! Our latest research on "Cell type directed design of synthetic enhancers" has been published in nature. We've harnessed deep learning to design enhancers with cell-type specificity. Find our paper here: nature.com/articles/s4158…. Highlights below: [1/n]

🔬 Delighted to share our lab's debut paper in nature. We unveil the first proof of autoreactive CD4+and CD8+ #Tcells infiltrating and targeting peripheral nerves in #Guillain-Barré Syndrome patients, reshaping our understanding of #GBS #autoimmunity. 👉 nature.com/articles/s4158…

Excited to share - EcORep! Now you can simply electroporate a PCR product into E. coli and let the linear DNA replicate orthogonally in the cell. EcORep can be used to evolve proteins rapidly and continuously! science.org/doi/10.1126/sc…

We are thrilled to present a new #enzyme to the world, the first shown to break the man-made carbon-silicon bonds in #siloxanes, which are persistent in the environment. caltech.edu/about/news/tea…

Read below about our exciting work that is now out nature led by @jcole_garcia of UC San Francisco Parker Institute for Cancer Immunotherapy Gladstone Institutes and Jay Daniels of Northwestern Feinberg School of Medicine. This is one of the most gratifying collaborations with Jaehyuk Choi -- tinyurl.com/nhdvhm6v

Our 2 bridge RNA papers are finally published in nature! Check out the incredible CryoEM structures, they're truly beautiful. A years-long rollercoaster ride, it's hard for me to imagine a more exciting project than this. Thank you to Nicholas Perry, Patrick Hsu, and our amazing team!

Happy to announce that two papers on the bridge RNA-guided IS110 recombinase have been published in Nature! Many thanks for the wonderful collaboration with Patrick Hsu. nature.com/articles/s4158… nature.com/articles/s4158…

Our work on bridge recombination is out in nature today. We are especially excited to share our structural work in collaboration with hnisimasu. We show that this enzyme makes and breaks a Holliday junction, using more (!) RNA-DNA base-pairing to drive the reaction forward 🧵

Sharing my first 1st author paper, now published in Science! For my PhD I engineered CHARM, a compact, enzyme-free epigenetic editor which can be delivered via AAV vector to reach the brain. This work was done in Jonathan Weissman's Lab with Tessa Bertozzi and Elaine Wu science.org/doi/10.1126/sc…

For 25 years, the Toll-like Receptor pathway was considered a series of distinct protein complexes that drive inflammation. Today, we report that the entire pathway, from receptor to transcription factor, is executed from within one complex—the myddosome. nature.com/articles/s4158…

My PhD work is out! How do mothers balance tending to their own needs, such as eating, and taking care of their offspring? We examined the link between feeding and parenting neural circuits and how they are modulated postpartum in mice 🧵 (1/9) PREPRINT: biorxiv.org/content/10.110…

BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the discovery of microRNA and its role in post-transcriptional gene regulation.

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Physics to John J. Hopfield and Geoffrey E. Hinton “for foundational discoveries and inventions that enable machine learning with artificial neural networks.”

BREAKING NEWS The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”

BREAKING NEWS The 2024 #NobelPrize in Literature is awarded to the South Korean author Han Kang “for her intense poetic prose that confronts historical traumas and exposes the fragility of human life.”

Our new paper on epigenome editing is out! We mapped which effector domains regulate transcription across genomic, cell type and DNA-binding domain contexts. Then we built new gene repressor and activator tools with improved efficiency & deliverability nature.com/articles/s4158…

ecDNA are rogue genetic material that amplify genes, contribute to treatment resistance and drive genomic heterogeneity. We report on the Origins and impact of extrachromosomal DNA today in nature nature.com/articles/s4158…

Introducing the 1,000 Flower Collection 🧬🌹 I’m creating 1,000 genetically designed flowers each crafted with new colors, patterns, and shapes. Here’s how I’m making it happen…  and how you can join me on this journey 🧵(1/7)

In the genomics community, we have focused pretty heavily on achieving state-of-the-art predictive performance. While undoubtedly important, how we *use* these models after training is potentially even more important. tangermeme v1.0.0 is out now. Hope you find it useful!