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Finally out our work showing the specific inhibition of melanoma-lineage identity genes using a new generation of ecteinascidin. Kudos to @MCigrang, Julian Obid and the only one Frédéric Coin at IGBMC ! nature.com/articles/s4146…

Today in Science Advances: "Chromatin Conformation, Gene Transcription and Nucleosome Remodeling as an Emergent System", in which CPGE researchers demonstrate that the human genome is an emergent, self-assembling, reinforcement learning system #chromatin science.org/doi/10.1126/sc…

Today in Science Advances: "Mature chromatin packing domains persist after RAD21 depletion in 3D". CPGE researchers integrated measurements of genome connectivity and physical structure to deepen our understanding of chromatin organization #chromatin science.org/doi/10.1126/sc…

Reactivating HOXD13 in cutaneous #Melanoma has a dual pro-tumorigenic role via re-shaping chromatin architecture 1⃣VEGFA/SEMA3➡️Angiogenic switch 2⃣CD73➡️⏫ extracellular Adenosine➡️⏬T-cell infiltration #SpatialTranscriptomics #Visium➡️Neg Corr b/w HOXD13 & cytotoxic T-cell

Excited to share our latest work, showing GATA6 is a critical regulator in colorectal cancer and 3D genome organization. Led by Huijue, Zoe and thanks to our wonderful collaborators Lu Wang_Northwestern U and Dr. Guanyu Yang. Lurie Cancer Center Northwestern Feinberg School of Medicine science.org/doi/10.1126/sc…

It’s #MRFResearchWednesday and today we’re highlighting the work of Dr. Pietro Berico, PhD, from NYU Grossman School of Medicine School of Medicine, NYU GSOM Pathology, NYUGSOM Interdisciplinary Melanoma Program, a recent MRF Career Development Award recipient. Discussing his work, Pietro Berico shares: “The skin is our

Thrilled to share our publication in PNASNews 🥳🎉🤩 that proposes a novel approach to enhance immune checkpoint blockade response by using thiopurine pnas.org/doi/10.1073/pn… Huge thanks to my amazing group & my great collaborator Kjeld Schmiegelow Melanoma Research Kræftens Bekæmpelse

This week, I was thrilled to kick off the immersion phase of University of Sydney’s PERIscope Commercialisation Award with co-winners & brilliant colleagues Dr. Nigel Maher and Dr. Ismael Vergara! 🚀 We are working to bring our incredible, novel diagnostic test to the public—one that

Another great preprint out from the Hernando lab, lead by M. Ángeles Gómez and Allie Kartz. Melanoma brain metastasis upregulate the carnosine dipeptidase CNDP1 through MITF to prevent intracellular copper accumulation? NYUGSOM Interdisciplinary Melanoma Program NYU GSOM Pathology biorxiv.org/content/10.110…

CPGE hosts an online archive of talks from world-class researchers on topics such as chromatin biology, super-resolution imaging, computational genomics, modeling, epigenetics, 3D genome structure, transcription and much more. Check it out at: physicalgenomics.northwestern.edu/education/virt… #chromatin

Perturb-tracing integrates CRISPR screening with barcode readout and chromatin tracing for loss-of-function screens, facilitating the study of chromatin folding regulators. Siyuan (Steven) Wang Yale School of Medicine Yale University Yale Department of Genetics Yale Cell Biology nature.com/articles/s4159…

(1/n) New preprint from clarice Fan Fang Varshini Ramanathan in collab w Jie Liu Q: How do we get ultra-high-res 3D genome maps? A: New deep learning model, Cleopatra. Cleo trains on Micro-C, fine-tunes on RCMC, and predicts genome-wide 3D maps biorxiv.org/content/10.110…

Our work on 3D genome organization in human cancer is out! In collaboration with Yanding Zhao Howard Chang William J. Greenleaf and TCGA we used HiChIP to profile enhancer connectivity and rewiring in primary tumors. nature.com/articles/s4158…

An atlas of TF driven gene programs across human cells biorxiv.org/content/10.110… #biorxiv_genetic

Why do some melanoma patients respond to immunotherapy while others don’t? Our new study links inherited mitochondrial DNA differences to treatment response, offering insights for personalized cancer care. ✍️ nature Perlmutter Cancer Center at NYU Langone Health 🔗 Read more: nature.com/articles/s4159…

Dr Milad Ibrahim of NYU Langone Health discusses EGFR, a promising therapeutic target in NF1 mutant #melanoma ecancer.org/en/video/12353…

Our scMicro-C paper is out in Nature Genetics! Huge thanks to the reviewers for their valuable insights, to SunneyXie for unwavering support, and to fantastic collaborators Jiankun Zhang & Longzhi Tan. Thrilled to share this work!

Congratulations to Honggui, Jiankun, and Tan for improving the single-cell 3D genome resolution by a factor of 4 (to 5 Kb). This allowed direct visualization that multiple enhancers cluster to a particular gene promoter at the same time in a single cell. nature.com/articles/s4158…

More than 2700 3′UTRs are highly conserved. These 3′UTRs are essential components in mRNA templates, as their deletion decreases protein activity without changing protein abundance. Highly conserved 3′UTRs help the folding of proteins with long IDRs. biorxiv.org/content/10.110…