Hoje começou o Salão de Iniciação Científica da UFRGS, que esse ano será online por causa da pandemia. Esse é o link do meu trabalho sobre biomarcadores astrocitários na doença de Alzheimer, desenvolvido com os colegas do Zimmer Lab 🧠🧬 youtube.com/watch?v=09bKrP…

So happy to finally share the most comprehensive meta-analyses of astrocyte biomarkers in AD. A result of a collaborative effort by João Pedro Ferrari-Souza Lucas Da Ros Douglas Leffa Rosa Neto, Pedro - Eduardo Zimmer 🦋 Elena Rodriguez-Vieitez. n.neurology.org/content/early/…

Could astrocyte biomarkers contribute to biologically understand AD🧠? Check out this amazing meta-analysis led by Bruna Bellaver! Very happy to be involved for the 1st time in a paper w/ this team Lucas Da Ros Douglas Leffa Rosa Neto, Pedro - Elena Rodriguez-Vieitez Eduardo Zimmer 🦋 n.neurology.org/content/early/…

🚨 In this study led by João Pedro Ferrari-Souza, we showed clinical evidence of astrocyte heterogeneity in the living AD brain. While CSF GFAP levels reflect a response to Aβ pathology, CSF YKL- 40 levels reflect a response to tau pathology. nature.com/articles/s4138… rdcu.be/cTp0C.

🚨Excited to see this paper out in #MolPsy! We found Aβ- and tau-specific contributions to reactive astrocyte biomarkers in AD rdcu.be/cTp0C👇. Thanks for all authors and funding agencies University of Pittsburgh McGill Research Centre for Studies in Aging UFRGS Tharick Pascoal Rosa Neto, Pedro - Eduardo Zimmer 🦋

This week I was at Caminha, in Portugal 🇵🇹 attending the International Society for Neurochemistry (ISN) Advanced School! Here’s a brief overview of what I experienced as a first-time attendee 🤓 #WeAreNeurochemistry 🧶

🚨 New Study just out in The Lancet Global Health 🧠 Lucas Da Ros, Wyllians Borelli, Cristiano Schaffer Aguzzoli & colleagues used a machine learning model to determine the most important risk factors for cognitive and functional decline in Brazil and other Latin American Countries 🧶1👇 thelancet.com/journals/langl…

🧩 Social and health determinants were more significant than classical demographics risk factors in all Latin American Countries, with important differences among them. 🧶2

📊 Education emerged as the most impactful risk factor for cognitive decline in Brazil, while Mental Health was the most impactful for functional deterioration. 🧶3

We could also see an impact of Brazilian geographical regions in the model for predicting risk factors for cognitive and functional decline. We evidenced worst cognitive scores in North and Northeast, while only Northeast presented worst functional scores. 🧶4

📢 Our findings point out the significance of individually understanding the risk factors for cognitive impairment and dementia in each specific region, rather than adopting a generalist, broad, one-size-fits-all approach. 🧶5

💪 This work was a team effort from 🇧🇷 UFRGS, PPG Bioquímica UFRGS, PPG Farmacologia e Terapêutica da UFRGS, Instituto do Cérebro do RS. 🧶6

We thank the co-authors: #MarcoDeBastiani, #JadersonCostaDaCosta, Tharick Pascoal, Rosa Neto, Pedro -, #LucasPSchilling, Hernando Santamaría-García, Agustin Ibañez, Claudia Suemoto MD PhD MSc, and Eduardo Zimmer 🦋. 🧶7

We also thank the funding agencies: Alzheimer's Association, CNPq, CAPES, Instituto Serrapilheira, Propesq UFRGS, and FAPERGS. 🧶8