#NatMetabPicks | In Cancer Discovery led by L Zitvogel, Camille Bigenwald et al (Gustave Roussy) Oral supplementation with Akkermansia spp. improves the efficacy of CAR-T cells against B cell lymphoma. aacrjournals.org/cancerdiscover…

A patient page for GLP-1 drugs and importance of integration of lifestyle factors with these meds jamanetwork.com/journals/jamai… jamanetwork.com/journals/jamai…

CAR-T cells containing CD28 versus 4-1BB co-stimulatory domains show distinct metabolic profiles in patients dlvr.it/TLwDHc

On the root cause of global obesity pnas.org/doi/suppl/10.1… science.org/content/articl… washingtonpost.com/wellness/2025/…

Engineering the gut microbiome in people with hyperoxaluria to avoid kidney stones science.org/doi/10.1126/sc… Science Magazine

Super excited to share new review on metabolic stress and adaptations in pancreatic cancer to these stresses from Colin Sheehan jci.org/articles/view/… 1/6

#Throwback COMMENT | Gary Siuzdak Subcellular quantitative imaging of metabolites at the organelle level nature.com/articles/s4225…

Nature research paper: Imidazole propionate is a driver and therapeutic target in atherosclerosis go.nature.com/4m6m6OZ

Review Nature Immunology The role of gut microbial metabolites in the T cell lifecycle nature.com/articles/s4159…

The rise of China’s pharmaceutical industry from 2015–2024 nature.com/articles/d4157… This new article analyses the growth in drug innovation in China, the underlying environmental factors and strategic trends such as the outlicensing of assets originating in Chinese companies

New #JITC article: T cell-specific non-viral DNA delivery and in vivo CAR-T generation using targeted lipid nanoparticles bit.ly/4m4iBIy Nadine Saber

I am thrilled to finally share my lab's first paper showing that sucralose consumption reduces immunotherapy efficacy in cancer, published NOW in Cancer Discovery ! Let's break it down. 1/n aacrjournals.org/cancerdiscover…

d-cysteine impairs tumour growth by inhibiting cysteine desulfurase NFS1 go.nature.com/45eETlB

Highly Efficient Gene Knockout in Tumor-Infiltrating Lymphocytes by Adenine Base Editing dlvr.it/TMdzjy

bioRxiv Controllable Sleeping beauty mutagenesis provides a platform for functional screening of genes that improve T cell therapeutic phenotypes, including a dose-dependent role of BACH2 in enhancing CAR-T cell function during chronic stimulation biorxiv.org/content/10.110…

New! Online now: NANOG Metabolically Reprograms Tumor-Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism dlvr.it/TMkFYT

Xylulose 5-phosphate fosters sustained antitumor activity of progenitor-like exhausted SLC35E2+ CD8+ T effector cells dlvr.it/TMrl06

RESEARCH | Britta Kunkemoeller, Hannah Prendeville, Lydia Lynch et al. (Trinity College Dublin, Harvard Medical School, Princeton University) Animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based fats do not. nature.com/articles/s4225…

Just published in Nature Communications! 🚨 We tracked #immune cell changes in blood during anti-PD-1 treatment and identified a non-invasive, early on-treatment biomarker of #immunotherapy response in #headandneck #Cancer. 🧵(1/5) 📜 doi.org/10.1038/s41467…

Our team is excited and honored to see our new method, HT SpaceM, for high-throughput single-cell metabolomics published in Cell! sciencedirect.com/science/articl… 👇