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NPX Ultras allow for "imaging" a 200x50 um region of the cerebellum with 30KHz sampling rate. Here are two examples. First a Purkinje cell. Notice the very large footprint and the prominent deep sounding complex spike. youtu.be/W0i6stwerDM Work of Mohammad Amin Fakharian

Next, a cell in the granular layer, likely a mossy fiber. Note the much smaller footprint and the thinner sounding spikes. youtu.be/9Awaw8tz3ss

Control of tongue movements by the Purkinje cells of the cerebellum biorxiv.org/cgi/content/sh… #biorxiv_neursci

We use our tongue for speech and mastication, skills that require control of more than 100 muscles simultaneously. These skills are degraded when there is cerebellar damage. What does the cerebellum contribute to control of the tongue? biorxiv.org/content/10.110…

👉New Methods and Resources paper in JNP "Rejuvenating silicon probes for acute neurophysiology" by Alden M. Shoup (Alden Shoup) et al. ow.ly/Kl5S50T23yU Reza Shadmehr Mohammad Amin Fakharian #SiliconProbes #rejuvenation #Neurophysiology

Mohammad Amin Fakharian’s birthday!

🎧Tune into the latest podcast with coauthor Alden Shoup as he discusses methods to rejuvenate #SiliconProbes in #neurophysiology research. Don't miss out on this solution for probe performance! 🎙️ow.ly/u3RH50TmMff Reza Shadmehr #impedance #recoating #rejuvenation

Very excited to see this paper outlined in a unique format! Extra thanks to everyone involved Natasha Porwal Mohammad Amin Fakharian Paul Hage Simon P. Orozco and of course Reza Shadmehr for your unwavering support. See our lab at #sfn2024 at posters 347.07, 172.07, and 347.09.

We believe that we have discovered a vector calculus for neural computation in the cerebellum: work of Mohammad Amin Fakharian Alden Shoup Paul Hage Hisham Elseweifi biorxiv.org/content/10.110…

Spontaneous recovery is a fundamental feature of motor adaptation, implying at least two timescales of learning. A new paper from Ali Ghazizadeh finds that reward learning also exhibits spontaneous recovery, and links it to the prefrontal cortex. biorxiv.org/content/10.110…

As you are reading this text, there is a storm of activity in your cerebellum. This is what it sounds like.

"I think there is only one way to science: to meet a problem, to see its beauty and fall in love with it, to get married to it and to live with it happily, till death do ye part." --Karl Popper Realism and the Aim of Science, 1983

In the cerebellum, neurons are placed in competition with one another, nulling the downstream effects of each other's spikes, in a well-organized subtractive process that produces a fast changing, precise output from a collection of slow, noisy neurons.

RT appreciated: We have a fully funded PhD position in CMC lab (at TU Dresden). You can use forms.gle/qiAv5NZ871kvQ1… to send your application and find more information. The deadline is April 30. Find more about CMC lab: cmclab.org and email me if you have Qs.

We previously showed that objects with stable values are found surprisingly fast among distractors—an effect not explained by classical search theories. Here, we show that reward-induced spatial processing enhancement in PFC underlies this effect. jneurosci.org/content/45/16/…

I’ll share more soon, but if you’re a prospective PhD student interested in ML theory, market and mechanism design, game theory, or optimization, definitely consider applying this fall!

Null space theory predicts that neurons generate spikes not only to produce behavior but also to prevent the undesirable effect of other neurons on behavior. In a new Science study, researchers show that this competitive cancellation is essential for understanding computation