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🧠 New insights into the genetic factors that drive Alzheimer’s disease 👉 Read here: vibbio.tech/3BsCK9I 🔬 Study led by Prof. Kristel Sleegers of VIB-UAntwerp Center for Molecular Neurology UAntwerpen BrightFocus Foundation Alzheimer's Association

1/ 🧵 So excited to finally share our preprint! Long-read sequencing of hundreds of diverse brains provides insight into the impact of structural variation (SV) on gene expression and DNA methylation- A new genomic resource for brain research! 🧠✨biorxiv.org/content/10.110…

Did you get your PhD in 2023 or 2024? With a background in bioinformatics and interested in understanding the social transmission of our microbiomes? 🦠👨‍👩‍👧‍👦🖥️ We can apply together for a Juan de la Cierva postdoctoral fellowship (internal deadline: 5/01/2025)

Do you want to start a PhD and study the transmission of the microbiome and alterations in neurological disorders? 🦠🖥️ We have a fully-funded position (deadline: 05/01/25)! All details: tinyurl.com/2b3sre8a Feel free to get in touch for more info!

Our mentor Casey Brown, apart from being an extraordinary scientist, was a brilliant teacher who loved everything genetics. In his honor, some of the world's leading experts came together to create the 'Casey Brown Lecture Series' on human genetics 1/ shorturl.at/eCm7S

We have beautifully showcased how important (good), collaboration is in order to move boandaries of what is possible :). If interested - check it out blog.vib.be/there-is-more-… Oxford Nanopore VIB UAntwerpen

Küçükali & Hill et al. integrate GWAS data with transcriptome and proteome-wide association studies to better understand risk factors for sporadic Creutzfeldt-Jakob disease, the most common human prion disease. tinyurl.com/4pn3sbub

Multiomic analyses direct hypotheses for Creutzfeldt-Jakob disease risk genes. Work with Elizabeth (Lizzie) Hill Fahri Küçükali Sleegers Lab to refine evidence for prion disease risk genes STX6, GAL3ST1. Adding MANF and PDIA4 for follow up work. Now published in Brain. academic.oup.com/brain/article/…

Multiomic analyses direct hypotheses for Creutzfeldt-Jakob disease risk genes academic.oup.com/brain/article/…

New online! The impact of rare genetic variants on Alzheimer disease bit.ly/4hpdUqS

🚨 New Review Alert! 🚨 Excited to share our latest in Nature Reviews Neurology! 🧠✨ We explore the impact of rare genetic risk variants on Alzheimer's disease, shedding light on key insights from recent studies. Thank you for this opportunity! #Alzheimers #variants #Review

Happy to see our preprint on Creutzfeldt-Jakob Disease GWAS gene prioritization is now published in Brain! Check it out here: academic.oup.com/brain/advance-…

biorxiv.org/content/10.110… I'm really pleased to share this preprint comprising the bulk of Lizzie Hill's work for PhD on the role of STX6 in prion and tau neurodegenerative diseases MRC Prion Unit at UCL Institute of Prion Diseases Elizabeth (Lizzie) Hill Short thread 1/n

Excited to share the pre-print on my PhD work demonstrating a role for syntaxin-6 in prion and tau pathogenesis. After 3 yrs of hard work, I am glad it is finally out and would like to thank my mentors and colleagues at the MRC Prion Unit for all their support Simon Mead MRC Prion Unit at UCL Institute of Prion Diseases

📣Excited to share my last postdoc paper with Soumya Raychaudhuri সৌম্য রায়চৌধুরী on eQTL mechanisms depending on where the RNA is in the cell! Brigham and Women’s Research Broad Institute TL;DR:Early RNA eQTL variants in the nucleus and late RNA eQTL variants in the cytosol have distinct molecular mechanism🧵👇

Last PhD paper is out, impact of miRNA genetic variants on neurodegenerative brain diseases! :) x.com/FrontGenetics/…

Ecstatic to see our paper "Long-read RNA sequencing atlas of human microglia isoforms elucidates disease-associated genetic regulation of splicing" now published in Nature Genetics with Towfique Raj Panos Roussos Friedman Brain Institute nature.com/articles/s4158…

Thrilled to share that our work is now published in Genome Medicine! I hope this can serve as a key resource for studying genomic structural variation in #Alzheimers and other neurodegenerative diseases. Check it out: doi.org/10.1186/s13073…

Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing nature.com/articles/s4146…