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I am super excited to share that my PhD work can now be found in bioRxiv! With Alphee Michelot we explored the physiological consequences and the molecular mechanisms by which highly similar actins can be specialized into different networks! IBDM biorxiv.org/content/10.110…

How cute is this!

It is unbelievable that one week ago I was defending my PhD thesis! Despite the obvious stress, it was such a wonderful experience.

After having a really bad experience some weeks ago where 15 doses of covid vaccines were trashed in front of my eyes in La Timone (Marseille), I finally got the chance to get vaccinated 2 days ago! I got Pfizer in Vaccinodrome and everybody was super kind. I'm really happy!

My PhD paper is finally out! Check it out if you're interested in how actin isoforms can preferentially assemble into a particular architecture. embopress.org/doi/full/10.15…

Why do eukaryotes need multiple #actin variants when others can do with one? Micaela Boiero Sanders Alphee Michelot et al CENTURI - Turing Centre for Living Systems show via gene swaps in yeast that specific key interactors segregate actin isoforms into distinct cellular networks embopress.org/doi/10.15252/e…

Learn about a new type of invasive multicellularity in a slime mold Fonticula alba! Great collaboration with Christopher P. Toret, Andrea Picco, Micaela Boiero Sanders, Alphee Michelot cell.com/current-biolog…

Now Micaela Boiero Sanders is growing yeast that express other yeast's actins. Most interesting. Eukaryotes tend to express loads of different actins. Why? #actin #ECF2022 European Cytoskeletal Forum meeting 2022

I'm honored to have been awarded the Humboldt-Stiftung postdoctoral fellowship! During the upcoming years I will keep working in the Stefan Raunser lab doing research on the #cytoskeleton using #cryoEM and #cryoET 🤩

The box manager is dead, long live the box manager! In the new crYOLO 1.9 version we replaced the old box manager with a napari-based box manager. Tutorials have been updated accordingly. Thanks to Markus Stabrin who did most of the work on this napari plugin! More in🧵👇

Have you ever wanted to determine protein structures directly inside cells using #cryoET? Then you should apply! We have Postdoc positions available MPI Dortmund #teamtomo #structuralbiology Max Planck Society More info here: nature.com/naturecareers/… #jobs

Happy #InternationalWomensDay An important day to remind us of the achievements and contributions of #WomenInScience we have to do more to support them in their challenging career! #WomensDay2023 #IWD2023

The latest work of my colleague Wout Oosterheert is out in #bioRxiv! 🤩 Wanna know how inorganic phosphate releases from the barbed end and the core of #actin filaments? Check it out!

TomoTwin is a generalizable deep metric learning-based particle picking method for cryo-electron tomograms. The method obviates the need for annotating training data and retraining a picking model for each protein. @gavinRice20 Thorsten Wagner @intein nature.com/articles/s4159…

Wanna know how actin filaments release inorganic phosphate (Pi) after ATP hydrolysis? Then you should check out this thread written by my talented colleague Wout Oosterheert! I'm super excited that our paper is now published in NatureStructMolBiol! 🤩

Big thanks to (twitterless) Vicky Trinkaus, Stefan Raunser and all our speakers for a stunning 2-day cryoEM/ET winter school MPI Dortmund - well timed to the first snowfall in Dortmund!

Curious about the molecular mechanism of #actin elongation by #formins? Then check out our latest work in Science Magazine! This was possible due to outstanding team effort. Big thanks to co-first author Wout Oosterheert, Bieling lab and @intein MPI Dortmund science.org/doi/10.1126/sc…

"One Ring to rule them all": Researchers from the groups of @peterbieling & Stefan Raunser Max Planck Society unveil at the molecular level how ring-like formin proteins promote actin filament growth in cells. ➡️mpi-dortmund.mpg.de/en/news/how-ac…

Micaela Boiero Sanders, Wout Oosterheert, Stefan Raunser and colleagues based at MPI Dortmund explore how the actin modulators phalloidin and DNase I interact with the pointed end of actin filaments. nature.com/articles/s4146…

Happy to share that our #openaccess review on the #molecular mechanisms of #actin filament polymerization and dissasembly is now online! cell.com/trends/cell-bi… Of note: This is likely my last post here. From now on you can find me @woutoosterheert.bsky.social. See you there