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🆕🔥ImpresU RCT Methenamine hippurate as prophylaxis for recurrent urinary tract infections in older women – a triple-blind, randomised, placebo-controlled, phase IV trial #IDXposts #UTIWiki clinicalmicrobiologyandinfection.com/article/S1198-…

🆕💫 Systematic Review and Meta-Analysis Cefepime versus Carbapenem Therapy for the Treatment of Invasive Infections with Inducible Chromosomal AmpC-Producing Enterobacterales #IDXposts academic.oup.com/ofid/article/d…

You are looking at the first ever image of another multi-planet solar system.

🆕💫Retrospective multicenter study Effect of temporary suspension of chronic immunosuppressive drugs on day-90 mortality and ICU-acquired infections among critically Ill patients with solid organ transplant #IDXposts link.springer.com/article/10.100…

Decision-making for management of immunosuppressive drugs in solid organ transplant patients admitted to the ICU remains controversial. Important study using a Bayesian approach #IDXposts

Released on this day in 1980.

A restful #summer weekend is anticipated today on #BowTieFriday. After months of #travel, I cherish a moment at home with family. Dr Leo Alex S. Aguirre, MD Michael Angarone Juan M. Masini Bob Mackey, The Bow Tie Education Guy Ak Sedai 🌟 Stephen David Beck Joe Thomas, MD, FHM Amar Kelkar, MD, MPH, FACP Michael Rockman, MD, PhD Stephanie

Excellent article raises the clinicians awareness about the dilemma of interpreting discordant CDI results! 🆕💫What’s Your C. diff-erential? Evaluating Clinical Management of Discordant Clostridioides difficile Two-Step Testing #IDXposts journals.sagepub.com/doi/abs/10.117…

Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 academic.oup.com/cid/article/78… Connor Prosty

🔥🔥Just published 🔥🔥 ATS CAP guidelines 2025 Diagnosis and Management of Community-acquired Pneumonia. An Official American Thoracic Society Clinical Practice Guideline Free access pdf American Thoracic Society (ATS) Thanks Ignacio uman #IDXposts atsjournals.org/doi/10.1164/rc…

A thread 🧵 ⬇️ - signed: an angry artist #NOAI

Yes. Writing is not a second thing that happens after thinking. The act of writing is an act of thinking. Writing *is* thinking. Students, academics, and anyone else who outsources their writing to LLMs will find their screens full of words and their minds emptied of thought.

We implore authors, peer reviewers, and journal editors to stop perpetuating the concept of static and cidal antibiotics, given the aforementioned evidence demonstrating it is a myth. #IDXposts journals.asm.org/doi/10.1128/aa…

Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 The reply is bizarre. ‘We agree that static/cidal is of no value, but we disagree that we should encourage people to stop talking about it because people still believe it.’ Indulging those people doesn’t change behavior. Time to call them out and give them a firm but polite, No!

Ozzy Forever!

Austin Camp Dr. 😷🦠🇨🇦 is on BlueSky🦋 Zayd Ahmad, PharmD, BCIDP Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 Todd C. Lee While most people agree that definitive therapy with vancomycin is probably not as effective as beta lactam for MSAA bacteremia, this has never been proven. All retrospective data. More important (cuz I believe it is inferior), the rationale for dual EMPIRIC Tx is weaker...

Austin Camp Dr. 😷🦠🇨🇦 is on BlueSky🦋 Zayd Ahmad, PharmD, BCIDP Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 Todd C. Lee 2 small retrospective studies purported to show vanco for 3 days followed by beta lactam for weeks for MSAA bacteremia was inferior to initial vanco+beta lactam. I find these studies biologically implausible to the point of hilariousness. I dont believe dual empiric is needed.

Austin Camp Dr. 😷🦠🇨🇦 is on BlueSky🦋 Zayd Ahmad, PharmD, BCIDP Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 Todd C. Lee I do believe that initial vancomycin should be switched to beta lactam if the blood cultures are MSSA, which, with modern diagnostics, can often be determined in 24-48 h. There is no way I believe not included beta lactam for 24-48 h makes a meaningful clinical diff.

I recently saw a patient with a serious infection. I prescribed the only effective oral antibiotic, but her insurance denied it. She’s still sick and is now at risk for sepsis. This is daily life for Americans. Meanwhile, the head of HHS is focused on the color of Froot Loops.

As #storms roll through the #Midwest ⛈️ I'm grateful for the #summer rain 🌧️on this #BowTieFriday Dr Leo Alex S. Aguirre, MD Michael Angarone Juan M. Masini Bob Mackey, The Bow Tie Education Guy Ak Sedai 🌟 Stephen David Beck Joe Thomas, MD, FHM Amar Kelkar, MD, MPH, FACP Michael Rockman, MD, PhD Stephanie Zach Radcliff (he/they) 🏳️‍🌈 Dhruv Srinivasachar MD (he/el/ele) KModyMD