I am so glad to share that Manisha Bairwa manisha bairwa and Ajeet Shukla Ajeet Shukla from Biocatalysis Lab got the best posters prize at 34th CRSI Symposium Chemical Research Society of India (CRSI) held at IISER Bhopal. Thankful to SERB and Centre of BioMedical Research, Lucknow for financial support to #biocatalysis

We have developed a biocatalytic system for synthesizing anilines through the enzymatic desaturation of cyclohexanone-derived imines: onlinelibrary.wiley.com/doi/10.1002/an…

In our second paper, we demonstrate that chiral silanols containing Si-stereogenic centers can be prepared enzymatically with high efficiency and enantioselectivity. These structures were previously believed to be labile under aqueous conditions. onlinelibrary.wiley.com/doi/epdf/10.10…

Mechanotransduction in the nucleus Multiple TFs transmit mechanical forces into transcriptional regulation. Nuclear shape, size, and chromatin abnormalities are common features of many diseases.

Here, the authors report an intriguing mechanism in the biosynthesis of swainsonine, a potent α-d-mannosidase inhibitor nature.com/articles/s4158…

As a follow-up to our previous work doi.org/10.1002/ajoc.2… .. an another cascade cyclization strategy leading to S(VI)- phenanthridines is now out ChemRxiv . Grateful to Anusandhan National Research Foundation for the funding to KhanLab doi.org/10.26434/chemr…

आज स्वतंत्रता दिवस के अवसर पर बाबासाहेब भीमराव अम्बेडकर विश्वविद्यालय, लखनऊ द्वारा समाज में अपना योगदान दे रहे कुछ वशिष्ठ व्यक्तियों को सम्मानित किया गया। इस क्रम में विज्ञान एवं अनुसंधान के क्षेत्र में यह सम्मान प्राप्त कर मुझे बहुत गौरव की अनुभूति हुई। Brajesh Pathak

Another exciting milestone in biocatalysis with nonheme enzymes! We have developed the first enzymatic system for copper-catalyzed radical C(sp³)–N coupling: science.org/doi/full/10.11…, which also represents the first demonstration of employing pterin-dependent nonheme enzymes in

Thiophenol-catalyzed radical hydroformylation unlocks sterically hindered tetrasubstituted alkenes→aldehydes! Our EROS-enlisted formyl radical precursor enables the development of novel drugs. J. Am. Chem. Soc. pubs.acs.org/doi/10.1021/ja…

A friendly reminder that the Central Dogma is NOT "DNA -> RNA -> protein." All that Francis Crick *actually* said was: “Once information has got into a protein it can’t get out again.” This negative statement — namely, that some transfers of information seem to be impossible —

Previously i also mentioned the same question on twitter

Genetically incorporating environment-sensitive noncanonical amino acids containing rotor-based fluorophores to target proteins enables real-time visualization of microenvironment changes in protein substructures nature.com/articles/s4158…

How complex life emerged on Earth, as well as how our bodies are made up of a wide variety of tissues have mystified humans for centuries. But Victor Ambros and Gary Ruvkun’s work on microRNA helps explain them. Learn more: nobelprize.org/prizes/medicin… #NobelPrize

What an Amazing Discovery! Scientists have discovered that Ants, after collecting grains and seeds which they need to store for the winter, actually break them into halves before storing in their nests. This is because by breaking the seeds into half, it stops them from

Engineered aminoacyl-tRNA synthetase mutants facilitate ultrafast bioorthogonal tagging with multiple noncanonical acids for multiplexed nascent proteome profiling in response to different cues in diverse bacteria nature.com/articles/s4158…

"I was not always the best student… but my teachers saw something in me." May-Britt Moser, inspired by her teachers, went on to uncover the brain’s "inner GPS," for which she was awarded the 2014 medicine prize. #WorldTeachersDay

BREAKING NEWS The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”