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Our latest work, published in Cell, identifies a rare soluble #tau species in human #Alzheimer’s brain that suppresses CA1 complex-spike bursting, a hippocampal neuronal firing pattern that is critical for learning and memory. cell.com/cell/fulltext/…

Online now: Selectively vulnerable deep cortical layer 5/6 fast-spiking interneurons in Alzheimer’s disease models in vivo dlvr.it/TKdvw6

Selectively vulnerable deep cortical layer 5/6 fast-spiking interneurons in Alzheimer’s disease models in vivo: Neuron cell.com/neuron/fulltex…

Where does Alzheimer’s begin in the brain? Our new study in Neuron reveals that earliest changes start deep in cortical layers 5/6, selectively affecting parvalbumin interneurons via reduced NPTX2 & GluA4. Restoring NPTX2 reversed deficits. cell.com/neuron/fulltex…

🧠 Paper alert! My scientific labour of love from my time at the UK Dementia Research Institute at UCL is now out in Neuron ! Deep-layer 5/6 PV interneurons show early dysfunction in Alzheimer's models in vivo, tied to NPTX2 and GluA4 loss. 🔗 cell.com/neuron/fulltex… 🧵Thread below ⬇️

Selectively vulnerable deep cortical layer 5/6 fast-spiking interneurons in Alzheimer’s disease models in vivo cell.com/neuron/fulltex… via Marc Aurel Busche et al

More great work from the Busche Lab that I’m glad to have played a part in. Now out in Neuron, we show that the earliest neuronal dysfunction in Alzheimer’s models is seen in parvalbumin interneurons in deep cortical layers.

Amalia Papanikolaou UK Dementia Research Institute UCL Neuron Very many congratulations! Great work!

Tau accumulation in Alzheimer's hampers burst firing in CA1 hippocampal neurons, crucial for learning/memory, independent of β-amyloid. Significant insights for AD research! PMID:40300603, Cell 2025, @Cell cell.com/cell/fulltext/… #AI #Pharma #BioMed #RNA #ASHG #ESHG

New research by Marc Aurel Busche identifies where Alzheimer's begins in the brain, revealing which layers and cell types of the brain are first affected 🧠 The study opens up potential new pathways for targeted therapies👉buff.ly/4GlltQF

Dysfunction without degeneration. Soluble, high–molecular–weight tau impairs neuronal burst firing, disrupting activity involved in memory formation. UK Dementia Research Institute ow.ly/sh6p50VTB7t

Great coverage by @Alzforum highlighting our latest findings in Cell! Very grateful also for insightful comments by colleagues including György Buzsáki, Grace Stutzmann, Brad Hyman, Nicolai Franzmeier & Sebastian N. Roemer-Cassiano.

Marc Aurel Busche Alzforum Cell Absolutely great story and totally agree with your finding, as Tau has both physiological and pathophysiological roles in synapse function and structure. Many congratulations 👏 🎉.

Hiring! We're looking for a postdoc to join my lab at the UK Dementia Research Institute @UCL. We’re investigating neuronal and circuit dysfunction in Alzheimer's, and developing innovative new treatments. Apply here👇 shorturl.at/LpCAq #Neuroscience #Alzheimers #Postdoc #Hiring #Dementia

A study led by Dr Marc Aurel Busche (UCL Queen Square Institute of Neurology, UK Dementia Research Institute) sheds light on the earliest stage of Alzheimer’s, identifying which layers and cell types of the brain are first affected. buff.ly/ex1ifjn

Great lab to join to make the real difference in Alzheimer’s disease field!

Glad to see our new paper finally out! We show how the GPR158 receptor controls synapse maturation and function by silencing an intrinsic inhibitory mechanism. authors.elsevier.com/a/1l7HS5Sx5g-Z… Work from Ben Verpoort and colleagues, with special thanks to our collaborators.