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Viruses aren't great but phages are actually useful. We see them as a treasure trove for genetic parts to power up our probiotic lactobacilli. Check out BMC how we found an overpowered promoter/repressor system for L. plantarum from a phage - doi.org/10.1186/s12934…

Engineering non-model probiotic bacteria can be challenging but eventually rewarding. In this study, we have tested multiple phage-derived repressors to end up with a nice story. Check it out if interested! Shrikrishnan Sankaran Varun Tadimarri 👏🏻👏🏻 …robialcellfactories.biomedcentral.com/articles/10.11…

We're looking for an enthusiastic PhD candidate who can explore innovative synthetic biology strategies to ensure biocontainment in engineered living materials being developed for environmental remediation. If that excites you, apply here - short.sg/j/43393108

Question to synthetic biologists working in Germany: which sequencing partner/company do you use for DNA sequencing? We are looking for an affordable and high quality option. Danke 🧬 #synbio #sequencing #DNA Varun Tadimarri Shrikrishnan Sankaran SOURIK DEY

Yesterday I had the pleasure to present the improved version of STRAIGHT-IN (v3.0) at #mSBW2024 in Boston. I was also glad to see some old colleagues and to meet new ones as well! Stay tuned for more 🧬

Extremely happy to see the protocol manuscript for the STRAIGHT-IN platform out online and featured as protocol of the week Nature Protocols.

Meet PEARL! We encapsulated lactobacilli in alginate beads, and they are secreting recominant proteins like pros! 🧬🧫 If interested, take a look at our latest work on Engineered Living Materials here: biorxiv.org/content/10.110…

Leibniz_INM Varun Tadimarri Marc Blanch Asensio Our talks were wonderfully complemented by talks from our Belgian collaborators Irina Spacova & Louise Dupont, who work with our engineered probiotic lactobacilli #ELM24

Presenting at #ELM2024 on our collaborative research on antiviral microbial therapeutics and their modification with Sarah Lebeer Shrikrishnan Sankaran Ilke De Boeck Ilke Van Tente Marc Blanch Asensio UAntwerpen Leibniz_INM. There is a bright future in engineering bacteria for human health!

Happy to present part of my PhD work involving the genetic engineering of probiotic bacteria at the #ELM24 Conference! Also, first time showing our latest work, PEARL, along with Varun Tadimarri 👏🏻 More will follow! 🧬

So you want to engineer your hiPSCs, but targeting DNA payloads requires multiple slow, inefficient steps for each construct. What if we could accomplish multi-site integration seamlessly? 🚨Introducing STRAIGHT-IN Dual! 🧵 (1/n) Link: biorxiv.org/content/10.110…

🚨Preprint alert! Excited to share the latest work of my PhD on bioRxiv. STRAIGHT-IN Dual allows the generation of homogenous genetically-modified hiPSC populations 1) in one week, 2) with ~100% efficiency, 3) in a markerless, near-scarless approach and 4) with two payloads!🧵⬇️

PEARL has reached the UK after my flash talk and poster presentation at the #synbio24 conference! Thanks a lot to the organizers Katie Galloway Tom Ellis Sonja Billerbeck and Yas 🧬 it was a really inspiring event. … and thanks to Prof. Wilfried Weber for the cool pic! 📸

New career goal unlocked: ✅ Attending the #SynBio24 conference with my twin brother Marc Blanch Asensio. Thanks Katie Galloway Sonja Billerbeck Tom Ellis and Yasunori for the amazing program and opportunity to present my last preprint STRAIGHT-IN Dual ⬇️ biorxiv.org/content/10.110…

I have a guess 🫢

Circuit not working? Time to check your syntax... #synbio MIT ChemE Dept MIT Dept of BE

Excited to share our latest research, "PEARL: Protein Eluting Alginate with Recombinant Lactobacilli", published in a peer-reviewed journal! It was a great team effort - check it out if you’re curious about our work: doi.org/10.1002/smll.2…

Who knew stuffing engineered lactobacilli in a gel would make them better at secreting our engineered proteins? A pleasant surprise for us and a great outcome for therapeutic engineered living materials - doi.org/10.1002/smll.2… Marc Blanch Asensio Varun Tadimarri Leibniz_INM

Dr.A.Blanch-Asensio🎓 Thrilled to share that I’ve successfully defended my PhD on advanced synthetic biology tools for stem cell engineering. >5+ years, we developed STRAIGHT-IN, a versatile platform for precise DNA integration in hiPSCs. Grateful for this incredible journey! 🧬