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Trio of studies, including this, ours & Ross Levine group. Tumor-infiltrating clonal hematopoiesis (TI-CH or CH-Tum) leads to: -worse cancer outcomes -inflammatory TME shaped by CH myeloid cells -potentially targetable changes sciencedirect.com/science/articl… biorxiv.org/content/10.110…

Excited to see BoneMarrowMap out in press! Please check out the R package (now capable of classifying 100,000 hematopoietic cells in 10 minutes) and consider giving the paper a read for some insights into how differentiation goes wrong in AML!

Absolutely thrilled to share with you the final version of EPIclone, out now (open access) in nature. This has been an amazing collaboration with the lab of Lars Velten (@larsplus) at Centre for Genomic Regulation (CRG) nature.com/articles/s4158…

What if this was a drug ?🙂 🆕 NEJM | June 2025 🎯 CHALLENGE Trial: Structured exercise after adjuvant chemo in colon cancer 📦 RCT | n=889 | Median FU: 7.9 yrs 🟠 3-yr structured aerobic program vs health ed alone 📈 Primary Endpoint: Disease-Free Survival (DFS) 🔹 HR 0.72

The most practice changing trial from #ASCO25 is now live on NEJM .If this was a drug, this would be approved today. Globally relevant and low-cost intervention that is not only delaying relapse but actually improving survival. Perfect case example of a #cancergroundshot trial.

Such a well deserved standing ovation for Chris Booth and the Challenge trial. These data are quite powerful. Much stronger evidence than what we saw in plenaries today. #ASCO25

Excited to announce our latest preprint is finally out! Huge collaborative work shared with Murtaza S. Nagree and supervised by Stephanie Xie! 😍 Check it here! biorxiv.org/cgi/content/sh… University of Toronto University Health Network Princess Margaret Cancer Centre

Scientists Cell Press reviewed 408 YouTube clips of sleeping cats and found 2/3 curled up on their left side. Here’s the neuroscience behind why:🧵 (Please watch their video abstract I put on the last post - it’s 100% worth it)

🚨 New paper in Nature Genetics ! How does cancer chemotherapy reshape the HSC landscape and drive the evolution of therapy-related myeloid neoplasms? We uncovered this process through single-colony WGS! See the full paper here! nature.com/articles/s4158…

Clonal hematopoiesis (CH, blood stem cells with mutations) is considered a risk factor for cardiovascular disease and other adverse health outcomes. But today we learn about its potential benefit vs Alzheimer's disease sciencedirect.com/science/articl…

Collaborative work online now Cell Stem Cell provides insight into how mutant immune cells can help mitigate Alzheimer’s disease. Tet2-mutant myeloid cells are able to infiltrate the brain and clear β-amyloid, slowing cognitive decline. cell.com/cell-stem-cell…

Congrats & thanks to Katherine King & Katie Matatall Katherine King MDPhD for inviting us to this collaboration Cell Stem Cell. Also to Alex McDonald, Marco Buttigieg , Caitlyn Vlasschaert & Susan Crocker Queen's Health Sciences Translational Medicine Graduate Program Queen's MD/PhD . Our funding from #NFRF SSHRC, CIHR

I'm honoured to share that I've been selected as part of the final CIHR #VanierCanada CGS cohort! Very grateful for the support from my supervisors Michael Rauh and Rob Vanner, as well as family, friends, and mentors from along the way! Queen's MD/PhD Sinclair Cancer Research Institute Queen's Health Sciences

We are excited to share our work on "closing the loop" 🔄 - a framework enabling single-cell foundation models (scFMs) to learn from experimental validation and dramatically improve their predictive accuracy! (1/n)

Germline genetic variation has been linked to both hematologic cancer and clonal hematopoiesis. But does germline variation influence the likelihood of CH progressing to cancer? And if so, why? We tackle these questions here in Nature Genetics nature.com/articles/s4158…

Delighted to share an updated review and our perspectives on clonal hematopoiesis and cancer in Nature Cancer in collaboration with Xiurong Cai and Bobby Bowman: rdcu.be/ewN62

We're super excited to announce the 10 recipients of our Sinclair Cancer Research Institute INAUGURAL 2025 Sinclair Graduate Scholars in Cancer Research awardees. Bravo and congratulations to Kaytlin, Marco, Simona, Samantha, Natasha, Monica, Fatin, Ashley, Laura & Julian!!!!

There are much more structural variants within our genomes than previously conceived, >26,000 per person nature.com/articles/s4158… nature.com/articles/s4158…