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Risk of cancer-related death for pts with ESKD is 2.5x higher than that of controls in the general population & this increased risk is largely due to new cancer among kidney tx recipients & to cancers that resulted in ESKD among dialysis pts bit.ly/2X3jSoD Stephen McDonald

Dr. Steven M. Brunelli, Adam G. Walker and Kathryn Gray's research abstract on the development and validation of a predictive model to identify patients with undiagnosed #chronickidneydisease is now available to #KidneyWk attendees: ow.ly/qfXo50C1dd3

Kidneys adapt in response to damage in its attempt to preserve normal function. Healthy nephrons take over the work of sick nephrons (just like you covering for your sick officemate). That’s why in early CKD, kidneys look “fine”. 1/2

More basic #GUPath points for our new 2023 trainees🔬 Whereas Gleason grading for #Prostate cancer focuses on ARCHITECTURE and totally disregard nuclear features … WHO/ISUP grading for #Renal Cell Carcinoma focuses on NUCLEAR FEATURES and discounts architecture. 👇👇👇👇

People with #KidneyDisease may have a higher risk of kidney #cancer due to: ➡️ Long-term dialysis ➡️ Immunosuppressant medicines On #WorldCancerDay, we raise our voice to ensure that all individuals have equitable access to cancer care. #WorldKidneyDay #CloseTheCareGap

Improving frozen section evaluation of procurement donor #kidneybiopsies and reducing the discard rate: a promising role for artificial intelligence doi.org/10.1016/j.kint… Original article: doi.org/10.1016/j.kint… Cedars-Sinai Academic Medicine #KICommentary #renalpath #transplantation

Uric acid crystals/microtophi: - associated with gout - occur in deep medulla - collecting ducts - can migrate from tubular lumens to interstitium - can have a granulomatous reaction - basophilic and polarizing when examining frozen sections From Dr. Biederman @renalpathsoc

Medulla only! Some diagnoses can be made in medulla only biopsy ⁃ Myeloma kidney ⁃ Light/heavy chain deposition disease ⁃ Amyloid ⁃ Crystals ⁃ sometimes ATN, interstitial nephritis, pyelonephritis Case showing large number of uric acid crystals in medulla:Urate nephropathy

Full version of GU Pathology Society (GUPS) GUPS and International Society of Urological Pathology ISUP white paper on defining indolent #prostatecancer is now available. An excellent product of the outstanding collaboration between the #GUPath societies. Congratulations to all! pubmed.ncbi.nlm.nih.gov/40444986/ 👇👇👇

Enjoy Kidney Cancer's Special Pathology Edition. A great set of [open access] RCC reviews; also, sarcomas, benign tumors, molecular changes, familial syndromes, grading/staging. Great for patients, clinicians, researchers & pathologists.🔬#gupath UroToday.com journals.sagepub.com/toc/kcaa/9/1_s…

A Day in the Sign Out- GU Path Gleason pattern 3: Doughnut-like structures Gleason pattern 4: Cinnamon roll like structures and poorly formed glands. Lot of subjetivity in this pattern, there is more than one correct answer most of the time Gleason pattern 5: Doughnut holes

Kidney disease develops quietly, with few noticeable symptoms in its early stages. We’re determined to improve outcomes for those living with #ChronicKidneyDisease (CKD). Discover how: unicycive.com/our-approach/

Thx Dan! Yes! So important to distinguish for appropriate patient care! ‘Shoulder’ of PUC is NCCN intermediate risk vs high risk for UCIS. It matters! 🔬

importantly can be a part of a systemic process or localized; important distinction!

#renalpath different pattern of IgG1(linear/granular) and IgG4(granular） in a patient with anti-GBM+ MN.

4: STAGE- tumor encroaches SV/EJ epith, worrisome for pT3b but not Dx-ic especially on prostate bx particularly not flagged as coming from SV ✅for these, I add comment & suggest they correlate with rads (FYI final RP here was pT3b) ✅can use PAX8 to highlight EV/EJ (👇🏽example)

Some well formed "eye lashes" on these capillary loops in a case of AL-amyloidosis. Podocytes getting skewered by the spicules in the EM. #renalpath #pathtwitter #nephrology.

#GUpath #grosspath correlation: myxoid degeneration in nephrectomy of clear cell RCC 🚨👁️gross & histologic🔬mimic of tumor cell necrosis (an important poor prognostic factor for clear cell RCC)

Looking forward to the upcoming GU Pathology Society (GUPS) Virtual Education Event on localized treatments in prostate cancer, featuring Jane K Nguyen MD PhD & Arvin K. George, MD Moderated by chemily ROHIT MEHRA & Dr. Liwei Jia! #GUPath Shivani Kandukuri, MD (she/her) @

🔬 BAP1-Mutated Clear Cell Renal Cell Carcinoma: Integrative Review with Emphasis on Genotype–Phenotype Correlation 1️⃣ Introduction Clear cell renal cell carcinoma (CCRCC) is the most common subtype of renal carcinoma. Its genetic basis is often marked by VHL inactivation, but