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Did Michelangelo paint a woman with breast cancer in the Sistine Chapel in Rome?🇮🇹 Nice article in The Breast Online👇🏻 The breast has consistently held a significant role in artistic representations and, in this case, also in its pathologies OncoAlert sciencedirect.com/science/articl…

Molecular Tumor Board of the University Medical Center Groningen (UMCG-MTB): outcome of patients with rare or complex mutational profiles receiving MTB-advised targeted therapy - ESMO Open esmoopen.com/article/S2059-…

Thrilled to share our new paper! Congratulations Sebastian Hollizeck⁩, Ning Wang, ⁦Dineika Chandra⁩ who led the work ⁦The Dawson Lab⁩ ⁦Peter Mac Research⁩ ⁦Collaborative Centre for Genomic Cancer Medicine⁩ Unravelling mutational signatures with plasma circulating tumour DNA nature.com/articles/s4146…

Gene profiling performed in the ALTTO trial reveals 5 subtypes within HER2+ #breastcancer, each with distinct prognostic and predictive implications. Immune-enriched #tumors show the best survival. #bcsm #biomarker #precisonmedicine nature.com/articles/s4146…

#SABCS24 beautiful discussion by Harold J. Burstein, MD, PhD, FASCO on EMBER3. One of the best!! A fabulous and well qualified accumulation of data attached. Wow. OncoAlert

Thank you OncLive.com for letting us highlight our work SWOG Cancer Research Network Cleveland Clinic Cleveland Clinic MD

Honored to have received the Clinical Scholar Award at SABCS 2024 for our research on BRCA mutations detected through ctDNA. Heartfelt thanks to my mentors, Massimo Cristofanilli and Emilio Bria Università Cattolica WCM Englander Institute for Precision Medicine Cristofanilli CTC Laboratory

One of the hardest things I do in #oncology clinic is translate results from a clinical trial to the #patient in front of me. In Nature Medicine, we introduce TrialTranslator, a #machinelearning framework for individualized #cancer trial emulation. nature.com/articles/s4159…

What is the impact of drug-drug interactions between palbociclib and proton pump inhibitors in #breastcancer? 💊 Can PPI use explain why the PALLAS trial was negative? Now out in ESMO Open our analysis of #PALLAS exploring this question👇🏻 OncoAlert authors.elsevier.com/sd/article/S20…

Cancer research currently lacks the concept of "timing a molecular event". How long ago did this mutation occur? Years, months or decades? There's a clever trick to do this though (partially). 🧵1/15

5,562 proteins were found to have tissue-specific enrichment across 32 human tissues. ◼️ The majority of them (3,088) are enriched at the protein but not RNA level. 🧠 The brain hosts the largest number of proteins that are only enriched at the protein level but not RNA level.

Another step close to De-escalation!! Neoadjuvant weekly nab-paclitaxel with trastuzumab and pertuzumab versus TCHP in patients with HER2-positive early breast cancer (HELEN-006): a multicentre, randomised, phase 3 trial - The Lancet Oncology thelancet.com/journals/lanon…

Comparative OS of CDK4/6is plus an AI in HR+/HER2− mBC n the US real-world setting 9146 pts 💥There were no significant OS differences between 1L palbo, ribo, and abema ‼️The median FU durations for the ribo and abema arms were much shorter than for the palbo arm

Survival with Trastuzumab Emtansine in Residual HER2-Positive Breast Cancer | New England Journal of Medicine ⁦OncoAlert⁩ ⁦NSABP Foundation⁩ ⁦NRG Oncology⁩ nejm.org/doi/full/10.10…

Cowabunga! Riding Breast Cancer's Biggest Data's Wave 🏄🏻‍♂️🌊🤙🏻from Literature 📖 Meta-analysis of 38,050 patients shows topical estrogen during TAM is safe, but caution with AI (2.5x recurrence risk). Mortality doesn't increase in either case! OncoDaily OncoAlert

Now published in Clinical Cancer Research! HER2 loss in not infrequent after treatment with T-DXd. Almost one third of treated patients had complete loss and an additional one third had decrease in HER2 IHC score! 𝗟𝗶𝗻𝗸 𝘁𝗼 𝗳𝘂𝗹𝗹 𝗮𝗿𝘁𝗶𝗰𝗹𝗲: aacrjournals.org/clincancerres/…

This video shows a subset of ribosomes inside a cancer cell actively translating mRNA molecules. Each point of light is one ribosome. An image was taken every 3 minutes over a 4-hour period.

TNBC treatment in the precision oncology era: -2 cm N0 TNBC: #KN522 -7 cm multi-node+ TNBC: #KN522 -PD-L1 neg: #KN522 -PD-L1 CPS >30: #KN522 -TILs 0%: #KN522 -TILs 70%: #KN522 -65yo pt: #KN522 -28yo pt: #KN522 -lobular TNBC: #KN522 -ductal TNBC: #KN522 -oligomet TNBC: #KN522

New npj Journals review👉Unraveling complexity and leveraging opportunities in uncommon #BreastCancer subtypes. 🔓pubmed.ncbi.nlm.nih.gov/39856067/ #JosePabloLeone Fresia Pareja Edi Brogi Christine Desmedt Malini Harigopal Caterina Marchiò Dr Sofia Merajver, MS, MD, PhD ☮️ Naoto T Ueno, MD, PhD Hannah Wen Dr. Steffi Oesterreich

What a thought provoking and stimulating ASCO for the breast cancer community! Still processing it all and looking forward hearing what others think of SERENA-6, DB-09, ASCENT-04 and beyond. #ASCO25 #CleClinicCancer