“NINJA” is a new tool for creating tumor cell lines with inducible neoantigen expression, which will help researchers study antitumor immunity. Read the study by Koch Institute at MIT, Brittany Fitzgerald, Martina Damo & Nik Joshi via Nature Biotechnology: go.nature.com/3giXNf2

Rocking our #IOYIF20 t-shirts and ready to explore the better parts of 2020! #squad #teamwork #mentoring

Martina Damo from Yale Cancer Center and Yale Center for Immuno-Oncology opened up our Friday sessions at #IOYIF20 with a discussion of her research into the mechanistic basis of immune-related adverse events (irAEs) associated with checkpoint inhibition.

SPOTLIGHT: Inducible de novo expression of neoantigens in tumor cells and mice Yale Medicine Koch Institute at MIT Nik Joshi Martina Damo Brittany Fitzgerald. Originally published in Nature Biotechnology. To read our summary click bit.ly/2PYJTmZ and scroll all the way down.

BREAKING NEWS: The 2020 #NobelPrize in Chemistry has been awarded to Emmanuelle Charpentier and Jennifer A. Doudna “for the development of a method for genome editing.”

OMG 🙏🏼😭 Thank you so much STAT Shraddha Chakradhar for writing this article about me. It is not just a story about me, but of the brave and brilliant people who I surround myself with. This is a story of every #womeninSTEM. statnews.com/2020/10/27/aki… via

What do trainees want from their mentors? Turns out, it's not so different from what people want in any other relationship. A top 10 list based on some recent discussions (and not-so-occasional missteps on my part):

It's official, our NINJA system/mouse paper is officially published in Nature Biotechnology! It had online publication (last August), but there's something special about the knowing there's a print version of a paper from my lab. nature.com/articles/s4158…

The PD-1 checkpoint receptor maintains tolerance of self-reactive CD8 T cell in skin biorxiv.org/cgi/content/sh… #biorxiv_immuno

Excited to announce our BioRxiv preprint describing how PD-1 promotes peripheral tolerance for self-reactive effector CD8 T cells in skin. This work led by Martina Damo. We think it explains (in part) how some cutaneous irAEs occur after PD-1 blockade. Tweetorial below 1/

Join us live next Tuesday 9am PT/12pm ET! Nikhil Joshi will present: "Blurring the line between T cell immunity and tolerance" youtube.com/watch?v=GDwG0h…

My lab is hiring! We are currently looking for an enthusiastic research associate w/ research experience who can work with a great group of trainees who are focused on figuring out how to use the immune system to defeat cancer. Apply with the link below. sjobs.brassring.com/TGnewUI/Search…

My lab is looking for two postdocs to work on funded projects in the lab. We are looking for individuals who are interested in developing and using cool animal models to ask cancer immunology questions. See website if interested: nikjoshilab.org/positions

The Nik Joshi had fun celebrating the past year’s events last night. Very proud to be part of this great group of scientists 😁

Our lab's latest paper on peripheral tolerance mechanisms in skin is out now in nature. Congrats to Martina Damo for leading this and thanks to collaborators from Krishnaswamy Lab and Yale Dermatology. nature.com/articles/s4158…

Thank you Yale University News for highlighting our study on the role of PD-1 in cutaneous tolerance and potential mechanisms of IRAEs to checkpoint inhibitors out now in @nature. Nik Joshi news.yale.edu/2023/06/21/stu…

A new study nature "Show for the first time that PD-1 has a critical role in preventing T cells from attacking normal tissues in healthy individuals,” Nik Joshi bit.ly/44uXt5N Smilow Cancer Hospital Yale School of Medicine OncoAlert Yale New Haven Hosp Yale Department of Immunobiology

Skin T cells, tolerance, and checkpoint control?! We loved this paper from Nik Joshi Martina Damo so much that Prof Frank Carbone came out of retirement to co-author this review!👩‍🔬👨‍🔬 nature.com/articles/s4159… nature Nature Immunology Doherty Institute

Excited to share that I have accepted a position as Assistant Professor at The University of Chicago and that my lab will open its doors in October 2023 as part of @UChicagoImmuno. Contact me if you are interested in studying mechanisms of peripheral tolerance with us!

My lab at the University of Chicago is looking for bright and motivated postdoc candidates to study mechanisms of immune cell regulation in health and disease. Contact me if interested!