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Please check out our new fine-mapping methods: SuSiE-inf and FINEMAP-inf! Huge congrats to Ran Cui et al 🎉🎉🎉

Meta-analysis fine-mapping is often miscalibrated at single-variant resolution dlvr.it/ScH8QK

Excited to share that our paper on asthma with the Global Biobank Meta-analysis Initiative (Global Biobank Meta-analysis Initiative) is out today in Cell Genomics!

The COVID-19 Host Genetics Initiative has released a manuscript covering the results from the latest data release. At 51 loci we can start clearly mapping biological pathways involved in COVID-19 severity and susceptibility. For example, entry defense by airway mucus. medrxiv.org/content/10.110…

🎉 Our #GWAS of gestational diabetes in #FinnGen is now available on medrxiv! We disentangle the genetic relationship of GDM with Type 2 diabetes using new methods we think could be much more broadly useful. A brief thread 🧵 1/7 medrxiv.org/content/10.110…

Out today nature – our analysis of the influences of common nuclear DNA variation on mitochondrial DNA copy number and heteroplasmy across >250,000 people across two biobanks! disq.us/t/4ibyjjo

An incredible illustration by @GitaPathakPhD on the genetic susceptibility to acute severe COVID-19 and SARS-CoV-2 infection. One glance - and you learn the critical genes involved in virus entry and host innate immune defenses needed to combat the virus. nature.com/articles/s4158…

4 years ago, we ran 16,554 GWASes for 7,271 traits across 6 ancestry groups and released the data to the public along with meta-analysis. After many careful dives through the results, we are happy to present these analyses on behalf of the Pan-UKB Project: medrxiv.org/content/10.110…

Could not be more delighted to present our work investigating how over 220,000 complex and molecular trait-associated genetic variants affect transcriptional regulation using massively parallel reporter assays! biorxiv.org/content/10.110… See below for a 🧵. 1/n

Excited to share our latest preprint introducing SAIGE-QTL, a powerful tool for single-cell eQTL analysis! Check it out here: medrxiv.org/content/10.110… #eQTL #scRNAseq #genomics (1/9)