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Huge team effort 🥳! thx to Johannes Sebastian Gnörich Laura Bartos Leonie Beyer Johannes Levin and many more!

🚨publication alert: image derived input function for [18F]PI-2620 quantification. An elegant way to perform kinetic modeling before selecting an appropriate reference tissue. Many thanks to Nico Franzmeier @GunterHoglinger Johannes Sebastian Gnörich Johannes Levin @RoemerSeb link.springer.com/article/10.100…

Super happy to share our new work in Brain by @RoemerSeb and MatthiasBrendel: in 4R tauopathy patients, we show that subcortical tau deposition is linked to hypoperfusion in connected cortical regions, suggesting a diaschisis-like disconnection mechanism. doi.org/10.1093/brain/…

So happy about this paper and all thanks to the help of MatthiasBrendel and our amazing lab and it’s PI Nico Franzmeier, as well as all scientist and clinicians at #LMU who helped to realize this project - @GunterHoglinger Johannes Levin

Biological definition of Parkinson’s disease is approaching 🚀 will this be „ATN“ for PD? much to do for the neuroimaging community! Many thanks to Silvia Morbelli Nathalie Albert @GunterHoglinger and the EANM NIC! link.springer.com/article/10.100…

Excited to share our newest work showing that neuroinflammation parallels tau spread in 4R tauopathies, suggesting a key role of microglia in tau progression. Many thanks to Maura Malpetti, @RoemerSeb, Johannes Levin, @GunterHoglinger and MatthiasBrendel doi.org/10.1002/mds.29…

Happy to be part of this cool cooperative project between Cambridge Maura Malpetti and the Munich 4R tauopathy team lead by Nico Franzmeier Johannes Levin MatthiasBrendel and @GunterHoglinger Stay tuned for the follow-up project on how tau, microglia and neuronal dysfunction are linked

'Regional desynchronization of #microglial activity is associated with cognitive decline in #AlzheimersDisease' Artem Zatcepin, Johannes Gnörich, Boris-Stephan Rauchmann... Matthias Brendel MatthiasBrendel Universität München @DZNE_en @SyNergy_Cluster bit.ly/4ecTMXa

Very happy to share our new work out in Alzheimer's & Dementia Journals, showing that combining PI-2620 tau-PET and fluid p-tau markers can help discriminate 4R tauopathies vs. AD. Huge thanks to first author Roxane Dilcher and co-senior MatthiasBrendel doi.org/10.1002/alz.14…

🚨 Just out in Theranostics: ☢️ we developed a new microglia specific Cu64-labeled TREM2-PET radiotracer ☢️ importantly this antibody based tracer has an integrated brain shuttle system (hTfR) to cross the blood-brain barrier. thno.org/v14p6319.htm #Theranostics

Pleased to present the design paper of a Dutch multicenter study in which we aim to assess the clinical value of Tau PET, led by Marie R. Vermeiren (Alzheimercentrum Amsterdam (inactief)). "The impact of tau-PET in a selected memory clinic cohort: rationale and design of the TAP- TAU study" Link to

Looking up all ~550 cases that we saw over ~10 years in our memory clinics, with both CSF and Aβ-PET obtained in clinical routine was a huge team effort, co-coordinated by MatthiasBrendel, @GunterHoglinger and colleagues from the University of Vienna and many others! Thanks to all!

Massive team effort across facilities at Universität München and @SyNergy_Cluster. Many thanks to MatthiasBrendel, @GunterHoglinger, Johannes Gnörich and many many many others!!! See also the previous Alzforum coverage on the preprint: alzforum.org/news/research-…

Happy to share our new work led by Johannes Sebastian Gnörich and MatthiasBrendel, suggesting a visual read algorithm for PI-2620 in 4R taupathies. Early imaging windows, kinetic modelling and basal ganglia are key! doi.org/10.1016/j.neur…

Check out our new work where we show that female sex is associated with a stronger Aβ-dependent p-tau secretion, potentially driven by elevated sTREM2-related microglial activation and stronger effects of ApoE4 carriership in women Nico Franzmeier MatthiasBrendel embopress.org/doi/full/10.10…

Happy to share Davina Biel newest in EMBO Mol. Medicine showing stronger Aβ-dependent p-tau increases in women, potentially driven by elevated sTREM2-related microglial activation and stronger effects of ApoE4 carriership in women Many thanks also to MatthiasBrendel! doi.org/10.1038/s44321…

Incredibly happy and proud to share our newest work in Science Translational Medicine showing that Aβ promotes neuronal hyperconnectivity, thereby driving tau spread across connected brain regions. Many thanks to to first authors Sebastian Roemer-Cassiano and Fabian Wagner! science.org/doi/10.1126/sc… Thread below

'Alpha #synuclein co-pathology is associated with accelerated #amyloid-driven tau accumulation in #AlzheimersDisease' Nicolai Franzmeier Nico Franzmeier Sebastian Roemer-Cassiano Alexander Maximilian Bernhardt...Johannes Levin MatthiasBrendel Günter U. Höglinger Universität München bit.ly/4bCVh0H