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We are seeking an enthusiastic health data scientist to work on drug target prioritization at the MRC IEU in Bristol emea3.mrted.ly/2j1jd#.X1YAD7S…

OpenGWAS currently down due to sever outage with our cloud hosting provider. Apologies to our users. Problem also affecting MR-Base

Artificial intelligence, a tool to predict adverse events in #CardiacSurgery. Insights into a field of unknow perspectives by Benedetto et al. #MachineLearning #EJCTS bit.ly/3oi2mdM

Novel SARS-CoV-2 Whole-genome sequencing technique using Reverse Complement PCR enables fast and accurate outbreak analysis biorxiv.org/cgi/content/sh… #bioRxiv

Our latest article has been published! The variant call format provides efficient and robust storage of GWAS summary statistics #VCF genomebiology.biomedcentral.com/articles/10.11… via Genome Biology

The variant call format provides efficient and robust storage of GWAS summary statistics now published in Genome Biology thanks to a massive collaborative effort from Shea J Andrews, Ben Elsworth, Tom Gaunt, gibran hemani and Edoardo Marcora rdcu.be/cdxdo #gwas #sumstats

There is no common format for reporting GWAS summary statistics. Matt Lyon, Andrews, gibran hemani, Edoardo Marcora and co show how the Variant Call Format can be adapted for this use. Compressed GWAS-VCF is faster than unindexed and uncompressed TSV genomebiology.biomedcentral.com/articles/10.11…

Join me at #ElasticCC where I'll be talking about how we use Elasticsearch for OpenGWAS. This is @Elastic’s free technical event from the community, for the community — happening from Feb 26 - 27 ela.st/community-conf…

We are recruiting two new posts to join the OpenGWAS team (MRC IEU): a research software engineer and a research data officer. bristol.ac.uk/jobs/find/deta… and bristol.ac.uk/jobs/find/deta…

Our recent effort is online now😃 biorxiv.org/content/10.110… george davey smith Tom Gaunt

Our latest preprint on detection of gene-interaction effects influencing biomarker concentration in UK Biobank. Performed using variance prioritisation with new #GWAS software (github.com/MRCIEU/varGWAS) Louise AC Millard george davey smith Tom Gaunt Kate Tilling NIHR Bristol Biomedical Research Centre (BRC) MRC IEU

GBMI multi-ancestry proteome MR is online now! Proteome-wide Mendelian randomization in global biobank meta-analysis reveals multi-ancestry drug targets for common diseases medrxiv.org/content/10.110… Tom Gaunt george davey smith @bmneale Wei Zhou Ben Brumpton gibran hemani

Our latest preprint exploring the feasibility of real-time risk prediction in pregnancy using automated modelling techniques with exemplar application to hypoxic-ischaemic encephalopathy. Heather White Tom Gaunt @DeborahLawlor2 @DavidOdd1

A community driven GWAS summary statistics standard biorxiv.org/cgi/content/sh… #bioRxiv

The first version of the GWAS-SSF format; a recommendation format when depositing GWAS summary statistics to public database such as NHGRI-EBI GWAS Catalog . "A community driven GWAS summary statistics standard" in bioRxiv #GWAS

💡Pleased to finally share a pre-print of our work integrating Mendelian Randomization and literature-mined evidence from EpiGraphDB to investigate breast cancer risk factors and their mediators Tom Gaunt Tim Robinson Yi Liu Ben Elsworth MRC IEU ICEP

Evidence suggests that lactase persistence may not have evolved because it allowed people to drink milk (who otherwise would not have been able to benefit from milk) Carl Zimmer nytimes.com/2022/07/27/sci… and paper nature nature.com/articles/s4158…

Examining the evidence for Mendelian randomization homogeneity assumption violation using instrument association with exposure variance medrxiv.org/cgi/content/sh… #medRxiv

Our latest preprint examining the instrumental variable homogeneity assumption using instrument association with exposure variance as a measure of effect modification Louise AC Millard george davey smith Fernando Hartwig Tom Gaunt Kate Tilling NIHR Bristol Biomedical Research Centre (BRC) MRC IEU