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In case you missed my paper that came out at the end of last year on the interplay between #actin biochemistry and mechanics at the structural level, I recorded a 12-minute talk summarizing the key findings.

Pleased to present our latest work, where we combine engineered filament capping complexes with Alvéole PRIMO micro-patterning of myosin motors to create a system for studying force-regulated actin binding interactions in higher-order networks biorxiv.org/cgi/content/sh…

Very pleased to present our latest work deciphering mechanisms of actin bundle construction by fascin from the Angstrom to the micron scale. A team effort by Rui Gong and Matthew Reynolds, and a great collaboration with Bidone Lab. bit.ly/3uorbNn

Hot preprint from Alushin_Lab on how the actin-bundling protein fascin flexibly interacts with actin filaments to build large assemblies:

Our latest work on #actin assembly is now online Science Magazine! We show how #formins bind and move with the growing barbed end of F-actin. Awesome collab. between Stefan Raunser and Bieling labs MPI Dortmund, and big thanks to co-first author Micaela Boiero Sanders science.org/doi/10.1126/sc…

Although I was selected as a Rockefeller University nominee for this year’s Regeneron Prize for Creative Innovation, unfortunately I was not chosen as a finalist. In the spirit of advancing open science, I’m posting my proposal here. (It’s supposed to be a “dream project” unrelated

Excited to present a new story, where we use purified proteins to reconstitute repair of mechanical damage in contractile actin networks by the LIM domain protein zyxin.

I received Firefly Petunias 🪴💡 from Light Bio about a month ago. An update: The plant arrived in a rough condition (somewhat expected). After a week, growth was still stagnant and flower petals wilted. In an effort to save it, I pruned it, transplanted it to a new pot with

Particularly excited to share our latest work, where we visualize how myosin motor forces alter the structure of actin. We discovered a spiral form of the filament which can be recognized by force-sensitive actin binding proteins. biorxiv.org/content/10.110…

Energy transformation machinery inside mitochondria

We are pleased to share our latest preprint on bioRxiv! Led by graduate student Lauren Vostal, we use chemical proteomics to profile VCP-DUB interactions in living cells. We identify DUBs that bind the entry, exit, or both sites of VCP's central pore. biorxiv.org/content/10.110…

Check out our latest work 😁

actin filament construction set

Our work on the regulation of the gamma-tubulin ring complex is now online Developmental Cell! Huge congratulations to all co-authors involved! Open access link to the paper: cell.com/developmental-…

Pleased to present our latest work, where we show that the cell-cell adhesion protein afadin coopts mechanically-regulated elements of the cadherin-catenin complex to drive cytoskeletal engagement. biorxiv.org/content/10.110…

1/n) Best way to start 2025! Thrilled to share our Nature paper about the structures of axonemal components from sperm flagella and from epithelial cilia of the oviduct and brain ventricles. Great collaboration with Tzviya Zeev-Ben-Mordehai and Alan Brown nature.com/articles/s4158…

Scientists in the Alushin_Lab have figured out how cells build a structure that lets them migrate. Unpacking these “finger-like” protein bundles that protrude from cells may lead to novel treatments for metastasis. #RockefellerScience bit.ly/3PKErmA

Some happy news. Pleased to see our paper showing how afadin strengthens cytoskeletal engagement by the cadherin-catenin cell adhesion complex out in Science Advances : bit.ly/3EFpD6h

Congratulations to my postdoc Matthew Reynolds Matthew Reynolds on receiving the prestigious Jane Coffin Childs Postdoctoral Fellowship! jccfund.org/fellows/class-… Matt will continue to work on the cytoskeleton within the cellular environment.