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The Genetic Architecture of Protein Stability nature 1/ 🧬 Simplified protein stability landscape: This paper reveals that the genetic architecture governing protein stability can be surprisingly simple. It demonstrates that additive energy models can predict phenotypic

⛰️🧬🥾Last weekend 30 Centre for Genomic Regulation (CRG) colleagues from both scientific and administration communities teamed up for a pilot #CitizenScience activity🧑‍🤝‍🧑, collecting water samples from Pyrenean lakes! #PyriSentinel Europa en el Pirineo 🇪🇺

Mark your calendars for the 8th Annual Mutational Scanning Symposium #VariantEffect25 "Mapping and Modelling Variant Effects at Scale"🗓️May 21-23, 2025 in Barcelona and online. Registration opens on Jan 20th, 2025. ℹ️varianteffect.org/mss2025 Centre for Genomic Regulation (CRG) IBEC

Excited to share our latest work. We introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/n medrxiv.org/content/10.110…

Opening the session on “Comparative genomic models of disease”, Elizabeth Murchison from Cambridge University talks about transmissible cancers and when cancer cells become infectious agents.

A major challenge in treating rare genetic diseases is the huge number of causal variants in different individuals. This led to assumptions that any given treatment would be suitable only for a small fraction of patients

Leveraging engineered #Pseudomonas putida minicells for bioconversion of organic acids into short-chain methyl ketones by Ekaterina Kozaeva, Manuel Nieto-Domínguez, Max Stammnitz @maxstammnitz.bsky.social et al. ACS Synthetic Bio Nikel SEM Group DTU Biosustain #OpenAccess pubs.acs.org/doi/10.1021/ac…

Introducing Human Domainome v1, the largest and most comprehensive library of human protein variants to date, which maps the effects of +500K mutations across 522 domains. The study by Ben Lehner and Toni Beltran Toni Beltran is out in nature. ✍️ Illustration by Queralt Tolosa, PhD