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Pleased to see our study in Nature Communications. We show the high threshold mechanosensitive channel could be allosterically modulated nature.com/articles/s4146… Understanding Life in Molecular Detail Leeds Integrative Membrane Biology Ion Channels @Leeds @belab.bsky.social Jon Lippiat BSRC St Andrews @ScienceLeeds School of Biology @news_RSE

Our latest study on MscL is now online. We employed DEER (PELDOR) & Deuterium access (ESEEM) in lipids to understand tension activation differences between two MscL orthologues In-lipid structure of pressure sensitive domains hints mechanosensitiv... sciencedirect.com/science/articl…

In our new RSC review we accumulated DEER/PELDOR studies of membrane proteins over 15 years ABC/Multidrug/Secondary transporters, to GPCRs, SEC transloc, Photosynth. & Mitochondr, OMPs, ion channels et al, combined with multiple lipid mimics and MD tools : pubs.rsc.org/en/content/cha…

Really pleased to see this online today in Structure - fantastic work led by Bolin Benjamin Lane Pliotas Group on the role of lipids and membrane tension in modulating the mechanosensitive ion channel MscL Kalli Group 🧫➡️💻➡️📊 Mass Spec Leeds Understanding Life in Molecular Detail sciencedirect.com/science/articl…

We are excited to host the RSC_ESR EPR conference University of Leeds Understanding Life in Molecular Detail @ScienceLeeds (27-30 March 2023), the first in Leeds after 37 years! An excellent line of plenary & invited speakers incl Bruker prize winner. Abstract submission is open: esr-group.org/conferences/20…

In our just accepted paper in Angewandte Chemie with RadfordLab & Neil Ranson in The Astbury Centre we used In-Cell PELDOR/DEER complemented by CryoEM to show the BAM complex adopts a lateral closed conformation in E coli cells in presence of antibiotic darobactin-B: onlinelibrary.wiley.com/doi/10.1002/an…

In our latest paper we monitor the entire conformational ensemble of the MscS ion channel by PELDOR/DEER under membrane tension generated by molecular means. Led by Benjamin Lane Yue (Mary) Ma Nana Yan & great Collab with Theodoros Karamanos Katrin_Ackermann @belab.bsky.social cell.com/structure/full…

It is a pleasure to have been involved in this project, and I'm glad to see it has been published."

Fascinating talk from our own group's Mary Ma Yue (Mary) Ma at the RSC_ESR meeting in Warwick competing for the JEOL JEOL EUROPE medal prize

It is an honor to have been selected for this Jeol prize talk, and I have received a lot of valuable advice and suggestions from other EPR experts.😃

Our study could pave the way for studying human TRP channel dynamics & monitoring of conformational and oligomeric ensembles by EPR (DEER / PELDOR). Great effort by Robin Bon & members of our group Anokhi Shah Yue (Mary) Ma Josh Wort Division of Molecular and Cellular Function UoM Manchester Institute of Biotechnology UoM Biology, Medicine and Health RSC_ESR International EPR Society

We reviewed recent pulsed #EPR Spectroscopy (PELDOR/DEER/PDS) applications on integral membrane proteins, enabled through Spin Labelling. Great to see the field moving forward! Anokhi Shah Josh Wort Yue (Mary) Ma Division of Molecular and Cellular Function UoM UoM Biology, Medicine and Health Manchester Institute of Biotechnology sciencedirect.com/science/articl…