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Authors Ralph Mazitschek Mark Tye Connor Payne Dyann Wirth Oppermann Lab MGH Center for Systems Biology Harvard T.H. Chan School of Public Health Broad Institute University of Oxford develop prolyl-tRNA synthetase high affinity inhibitors as antimalarials from a single-step biochemical assay. go.nature.com/3AUW5NK

Preprint out! KEAP1-CUL3 structure, an awesome new assay platform for BTB domain-containing proteins, and elucidating the mode of inhibition of CDDO...what a fantastic collaboration Ralph Mazitschek MGH Center for Systems Biology Centre for Medicines Discovery biorxiv.org/content/10.110…

My Saturday fun project: using AI, every US president as a Pixar character.

I wonder if we will see certain footage played in reverse to suggest some “visitors” just came to fix things that were broken.

Awesome collaboration with #BullockLab and Connor Payne! Combining our complementary expertise, we shed new light on the CUL-3-KEAP1 complex, establish a straightforward assay to measure CUL3 binding to its adaptor proteins, and reveal CDDO’s activity as a “partial antagonist”.

Rockstar work championed by Connor Payne and Saki Ichikawa synergistically combines #CoraFluors and #Cyclimids into a powerful platform approach to accelerate degrader development and comprehensive characterization.

What if great scientists had logos [✏️ Kapil Bhagat & Prateek Lala]

Excited to share 2 preprints, together showing how mechanisms of a molecular glue & E3 ligase cancer mutations serendipitously converge to cause neomorphic protein degradation in distinct contexts. Highlights below: 1/17 #1: biorxiv.org/content/10.110… #2: biorxiv.org/content/10.110…

Excited to see this out! Congrats to Forrest Hammel and the whole team!! Connor Payne Ralph Mazitschek Harvard Micro Identification of a Polypeptide Inhibitor of O-GlcNAc Transferase with Picomolar Affinity | Journal of the American Chemical Society pubs.acs.org/doi/10.1021/ja…

Voices: Albert A. Antolin (he/him), Yimon Aye, Liron Bar-Peled, Elena De Vita, Nata Dudkina, Michael C. Jewett, Hannah Kiely-Collins, Ralph Mazitschek, and Zhenrun Jerry Zhang define "What is Chemical Biology." dlvr.it/TDRhvs