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Despite our scientific success Novo Nordisk Foundation will close CPR due to new funding strategy. #forskpol #DKforsk We applaud our visionary leader Jiri Lukas for creating a global flagship in protein research whose pioneering spirit will live on #CPRlegacy. How did he do this? 👇🧵

Congrats to Justine Stehn, Scott Floyd, and Yi Kong on what I hope will be the first of a series of papers showing alterations in protein translational control after DNA damage through stress signaling and 14-3-3. frontiersin.org/articles/10.33…

If we didn’t have tenure scientists never would have risen up to discard our dysfunctional publishing system

Great work from the David Cortez lab! doi.org/10.1126/scienc…

RNA Damage? Happy to share Jung-Kuei Chen and Karl Merrick and YaffeLab preprint that reports the major mechanism of 5-FU action in clinically relevant cancer treatment is through damage to structured RNAs...biorxiv.org/content/10.110….

In the bioRxiv paper, we find that 5-FU shows no synergy at the cellular level with the DNA damaging drugs oxaliplatin or irinotecan - the combination given for GI cancer Rx. Instead, ribosome and tRNA biogenesis is impaired, driving an apoptotic signal that does not require p53

Very grateful to our collaborators at Genentech, Adam Palmer's lab, Adam C Palmer, Matt Vander Heiden's lab, MVH Lab, and Omer Yilmaz's lab Omer Yilmaz, and of course the Koch Institute! Koch Institute at MIT

Links between translation and alternative polyadenylation in metastasis? The story is out today! A great collab between Hani Goodarzi, Andrei Goga and Faraz K Mardakheh labs! Shout out to co-authors Hossein Asgharian, Juliane Winkler, @lisacfishsci among others! nature.com/articles/s4155…

Fantastic motifs and signaling meeting at EMBL the last 2 days in honor of Toby Gibson.

This is truly brilliant… youtu.be/5uFwyPP5GOQ

threadreaderapp.com/thread/1776280…

This is a really important thread from Lior Pachter about the mathematical underpinnings of scRNAseq.

Thrilled to share our characterization of the human tyrosine kinome. Try out the public website: kinase-library.mit.edu/home Wonderful collaboration with Cantley Lab Turk Lab YaffeLab. Many years of work led by Jared Johnson! nature.com/articles/s4158…

This is rich - one of the primary reasons scientists don't have a lot of time to think is that @nature and its ilk have promoted a culture where the primary goal of science is to produce bloated Nature papers that require lots of time and money, but little thought, to produce.

nature.com/articles/s4158… Thrilled to share this latest work led by Xiao-Kang Lun in Peng Yin's lab and Xueyang Yu in mine. Finally, single cell signaling can begin to rival single cell RNA-Seq, using CyTOF, phospho-antibodies and ACE amplification.

Thrilled to share our latest story on 5-FU inducing RNA damage during ribosome biogenesis - cell.com/cell-reports-m…. The whole thing started when Karl and Jung-Kuei were trying to figure out hiow limiting dNTPS skewed DNA repair. Never thought it would be RNA and tge ribosome!

Special thanks to Adam Palmer's lab, Matt Vander Heiden's lab, Omer Yilmaz's lab, and the folks at Genentech, all of whom were instrumental in this 5-FU story about RNA damage! Collaborative science is always the best!

Scientists and universities: defend indirects as a concept but not current indirect rates. Don't think there's waste in those numbers? We (US science) spend $4.5 billion on journals. That is HALF of the proposed cuts in indirects, and eliminating that spending would make science