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Very happy to share our latest work on comparing the rules by which antibodies are assembled (VDJ recombination). Turns out, these rules differ across individuals (even twins!) with implications for the probability with which each individual generates antigen-specific antibodies.

Types of AIRR Papers in two chapters – because we had too many good ones 😂. A team effort of the Greiff and Geir Kjetil Sandve lab members. airr_community

AIRR ML: Did you know that baseline machine learning methods can perform well even when disease-associated signals are present in only 2 out of 100 000 receptors in diseased adaptive immune repertoires? Check our latest preprint: biorxiv.org/content/10.110… 1/10

My first paper is out! 🎉 Had a lot of fun fighting with the reviewer 6

Happy to share our preprint: "A billion synthetic 3D-antibody-antigen complexes enable unconstrained machine-learning formalized investigation of antibody specificity prediction" biorxiv.org/content/10.110… Check out Absolut! database+software to simulate more github.com/csi-greifflab/…

Another new preprint! We combined virtually-docked 3D-antibody-antigen binding complexes with an unbiased in silico oracle to explore at unprecedented resolution the principles of ML-based antibody design with respect to affinity, conformational epitope, and developability. 1/2

One of my PhD projects is devoted to the tandem analysis of antibody proteomics and genomics data. In the review we explain why this problem is really tough and important. More cool papers are coming soon! Stay tuned :)

immuneML is now certified as AIRR-compliant by the AIRR community software working group! 🎉docs.airr-community.org/en/stable/swto… airr_community the new AIRR-compliance badge is now at github.com/uio-bmi/immune… 😎

Fantastic news from our lab: ~1000x speedup for compairrson of large immune repertoires! Check out CompAIRR github.com/uio-bmi/compai…

Our study "Individualized VDJ recombination predisposes the available Ig sequence space" is now published in Genome Research 🥳 genome.cshlp.org/content/early/… Congrats Andrei Slabodkin et al.!