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Looking forward to visiting Toronto to talk about the good, the bad and the ugly of Mendelian randomization

Looking forward to being in Toronto on Friday

Join us to hear from Dr. George Davey Smith from University of Bristol on "Mendelian Randomization – what it was, what it is, and what it should become." 🗓️ March 7, 2025 | 12-1 pm ET | bit.ly/4ke7DjK | Open to all george davey smith #StatisticalGenetics #GeneticEpidemiology #STAGE

Liveposting on Bluesky: george davey smith (GS): Mendelian randomization: what it was, what it is, and what it should become bsky.app/profile/michae…

Contralateral cancers are an enigma: the unaffected organ is perfectly matched on exposures across life. Yet at older ages, risk of cancer in the unaffected organ is not much higher than in a randomly selected organ from the same population. How & why? youtu.be/7rbsGpz9-XE

Is there a future for Mendelian randomization? 10th March 11.00 Canadian time, online and in person McGill University, I'll discuss this and why, if I had been better read, I would have used the term "meiotic randomization" rather than "Mendelian randomization" in the initial papers

Lifecourse epidemiology debuted in 1997 with “A Lifecourse Approach to Chronic Disease Epidemiology” edited by Di Kuh & Yoav Ben-Shlomo. The 3rd edition of the ground breaking book is being launched 12 March 15.30 UK time bristol.ac.uk/integrative-ep… & foreword bristol.ac.uk/media-library/…

Se lanza la 3ra Edición del libro que formalizó un enfoque de curso de vida para la epidemiología contemporánea 👇🏽

the "butter bad dark chocolate bad" authors have been producing nonsense for 40 years .. see ieureka.blogs.bristol.ac.uk/tag/george-dav… and youtube.com/watch?v=8IgpTT…

Thought for the day, from Conrad Waddington in 1969 “Life might be defined as the art of getting away with it; and Theoretical Biology as the attempt painstakingly to explicate just how it is done”

It’s 5 years from intensification of covid policy in the UK, and the mantra of “lives vs economy” becoming common place. Here a long thread from soon after, reflecting on the fact that there was so much more at stake that “lives vs economy”. It was “lives vs lives” that mattered

What’s the point of the Labour party? theguardian.com/commentisfree/…

The advent of Mendelian randomization followed the myriad cases of observational studies suggesting vitamins would prevent many diseases, with RCTs quashing these hopes. Sadly fallible MR methods simply recapitulate the spurious epidemiological findings academic.oup.com/ije/article/54…

Reposted with suggested listening for playing when reading the editorial youtube.com/watch?v=GGeOo2…

My favourite visual representation of Mendelism is below, but as always the story is more complex than it seems ieureka.blogs.bristol.ac.uk/2022/07/15/the…

Triangulation of evidence in medical research explained, in work led by Sirena Gutierrez and Maria Glymour link.springer.com/article/10.100… Will do a thread when I get the time

Absolutely NO causal relationships can be drawn from this paper due to the high risk of selection bias in the design. The 'control group' consists of only 2,509 children compared to the overall cohort of 73,254 children, and only 5 were diagnosed with autism.

Really important reply on recent claims being made in the Covid inquiry by some unelected/ unaccountable scientists.. important that science advice is not dressed up as political ideology