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Scientists uncover “fat-to-neuron” communication that regulates longevity. DGLA, a fatty acid derived from intestinal lysosomal lipolysis, binds to the lipid chaperone protein LBP-3 to induce neuropeptide signaling and promote longevity. meng wang ow.ly/F8lg50Jvus5

Our first proteomics work on lysosomes. Finding things never expected.

Inhibiting mTor or IGF/Insulin and improving lysosome function extend lifespan. But how? How do they affect different cell type at single-cell level? Very surprising findings as we perform single-nucleus RNAseq of the whole worm with ⁦meng wang⁩ biorxiv.org/content/10.110…

Learning about pro-longevity mechanisms at the single-cell level. With Hongjie Li Yusi Fu biorxiv.org/content/10.110…

Online now: Mitochondrial GTP metabolism controls reproductive aging in C. elegans dlvr.it/Sw35Kf

🔥New research led by Janelia Sr. Group Leader Meng Wang (meng wang) identifies a mitochondrial enzyme that regulates reproductive health in C. elegans, a novel finding that could help scientists better understand human reproductive aging. 🧵(1/6) janelia.org/news/researche…

Quantitative Profiling of Lysosomal pH Heterogeneity using Fluorescence Lifetime Imaging Microscopy biorxiv.org/cgi/content/sh… #biorxiv_cellbio

New findings uncover the role mitochondria play in female reproductive aging. Scientists HHMI | Janelia led by Meng Wang (meng wang) gain important insights that they hope will lead to improved fertility and IVF outcomes. Read the full post: ow.ly/zxaR50PUAJC

🧪Research led by Sr. Group Leader Meng Wang (meng wang) details how lysosomes change their protein composition as organisms become long-lived, providing insight into the role these organelles & their associated proteins play in regulating longevity. 🔗janelia.org/news/researche…

Learning about C. elegans aging at the single-cell level.

Chemical Induction of Longevity-Promoting Colanic Acid in the Host's Microbiota biorxiv.org/cgi/content/sh… #biorxiv_devbio

"Diversity is really important in science. First of all, I think that if you want to have the best scientific outcomes, you need a lot of different brains working on it." - Chemistry laureate @doudna_lab on diversity in science. Read the interview: bit.ly/2M82Chu

A fun learning experience through working on this review article. The interactions between bacteria and host organelles unfolds at various levels.

Truly honored, as my career path has been greatly influenced by my engagement with the ASCB society American Society for Cell Biology.

🔬 Join us at the Aging & Microbiome Conference in Jena! 🌟 A first-ever event to discuss cutting-edge science and clinical applications in aging and the microbiome. Don’t miss out—register today! 👉 indico.leibniz-fli.de/event/2/ #AgingResearch #Microbiome #microverse #AMC2024

📢 Applications are open! Join us at the intersection of cellular physiology & #AI to discuss how AI technologies can help unravel the mysteries of genomes & cell structures & answer biological questions Learn more + apply by Nov. 5 @ janelia.news/4DCP25 #cellbio #AI

Go Gary! 🍾Gary Ruvkun We're all so happy for you!😊

A fantastic meeting #MetabolismInAction2024. Thanks Eleonora Nigro for your awesome science illustrations!