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Move over STING, TRIF and MAVS. IRSp53 and GMIP join the club of pLxIS proteins that stimulate interferons. So pleased to share our new study, which used synthetic biology to reveal multiple mechanisms that lead to anti-viral immunity. With a surprising link to metabolism.

New work from our lab’s genomics guru Artem Khan with Eric R. Gamazon. Artem generated a new platform for metabolic gene discovery and identified the mitochondrial choline transporter. Rockefeller University Nature Genetics nature.com/articles/s4158…

Super excited to share a preprint from my postdoc in the Rabinowitz lab on how metabolism changes during viral infection biorxiv.org/content/10.110…

Today was surreal! Thank you to everyone who came in person and virtually, especially my awesome committee Will Bailis Kellie Ann Jurado Dr. Sunny Shin Cornelius Taabazuing and Igor Brodsky for being such an amazing thesis advisor!

Delighted to share our work developing an mRNA vaccine for C. difficile, published today in Science Magazine. This study with The Drew Weissman Lab was co-led by two truly amazing scientists: Alexa Sem from the Zackular lab and Mohamad-Gabriel Alameh (now at CHOP Research)! science.org/doi/10.1126/sc…

Excited to share a new preprint! Using solution #NMR spectroscopy, we explored the #dynamics of the #cytokine interleukin-2 and ‘superkine’ variants, identifying a core allosteric network that enables enhanced receptor binding. Greg Bowman SpanglerLab doi.org/10.1101/2024.1…

This is a list of blockbuster drugs in 2024. Guess how many can trace their origins to NIH funded research? All of them.

This is a thread on our paper by Eric Fagerberg . KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection science.org/doi/10.1126/sc…