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A full expansion on the theoretical basis for the #MuSyC drug synergy framework, first published in Cell Systems , now up on bioRxiv. Multi-disciplinary work funded by #NSFfunded @NSFGRFP and @NCIsysbio #CSBC. Quaranta Lab Carlos F Lopez disq.us/t/3g275po

WOO! Just got the "official link" for sharing from NPJ Sys Bio and Applications... In this work we show how the flux and Channel Capacity of a signal through a network changes with protein concentrations. The analysis required ~20K CPUs & 1.5M CPU hours! rdcu.be/bKOUK

"Cancer is a dynamic process, and yet our treatments are static." Our commentary on how cancer dynamics might shed lights on new vulnerabilities. Quaranta Lab Dynamics of drug response informs rational combination regimens stke.sciencemag.org/content/12/595…

I am pleased to share our in-depth review on drug synergy is now available from Trends in Pharmacological Sciences. Special thanks to Quaranta Lab and Carlos F Lopez for their contributions and @NSFGRF and @NCIsysbio which fund this work. #NSFfunded #drugsynergy sciencedirect.com/science/articl…

Really nice overview by the Quaranta Lab on assumptions on biology and data made by different #DrugSynergy models. This is critical when choosing the right synergy model for your data! sciencedirect.com/science/articl…

Carlos Lopez & Vito Quaranta tackle issues impacting all aspects of combination therapy discovery and deployment in this CellPress review article titled "Charting the Fragmented Landscape of Drug Synergy" bit.ly/2Im7VUN Cell Press Quaranta Lab Carlos F Lopez Christian Meyer

This week in the field of mathematical oncology: issue 105. <glioblastoma models, drug synergistic effects, the cancer microbiome, organoid dynamics> buff.ly/3atSpCC

A Bayesian framework for intelligently deploying universal COVID testing: disq.us/t/3wgezdl Related to the recent, fantastic article by Tom Chivers in The Guardian theguardian.com/world/2021/apr…

Happy to share our paper online today at Cytometry A describing DebarcodeR - an algorithm for demultiplexing fluorescence cell barcoded (FCB) flow cytometry data. (1/12) Jonathan Irish @BrianOBachmann onlinelibrary.wiley.com/doi/10.1002/cy…

Woo! Finally. Check out our paper: MuSyC is a consensus framework that unifies multi-drug synergy metrics for combinatorial drug discovery, w/ Quaranta Lab #NSFfunded #NIHfunded #whatweneedmoreofistheory rdcu.be/cqKIo

.Christian Meyer Quaranta Lab Carlos F Lopez AL present #MuSyC, a consensus synergy metric for characterizing combinatorial drug interactions. #MuSyC overcomes several caveats associated with popular synergy metrics. go.nature.com/2VxQTNE

Thanks for the shout out!

Pleased to share our preprint on bacterial zombies! These zombie cells are non-viable but they reshape the antibiotic tolerance of other species via paracrine secretions. Great working with The Kralj Lab alumni @BruniGN and Ben. BioFrontiers 💻🦠🧬🧪🧫💉📊📓 CU Boulder 🦬 biorxiv.org/content/10.110…

Next up at #MPDD is Christian Meyer discussing MuSyC They have a webapp musyc.lolab.xyz

OUT NOW A High Throughput and Low Waste Viability Assay for Microbes by Christian Meyer dana 🌿🕷 nature.com/articles/s4156…