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We used our “humanization” strategy in Drosophila to study the genotype phenotype correlation for Peroxisome biogenesis disorders. biorxiv.org/content/10.110…

We’ve had a real push to leverage Drosophila models to understand disease mechanism in Peroxisomal disorders. We are at the “all at once” stage for our studies on peroxisomes in disease. biorxiv.org/content/10.110… biorxiv.org/content/10.110… biorxiv.org/content/10.110…

Congratulations Baylor Genetics!

Dog saves dog.. 😊

PhD position available at the Institute of Human Genetics Universitätsklinikum Heidelberg and Uni Heidelberg , start date February 2025.

Flybrain> Banana. My entry for the art in neuroscience competition at QBI.

In May 2000, with the generation of a working draft sequence of the human genome nearly complete, Human Genome Project scientists (including myself) started speculating about the number of human genes.

So happy for my PhD student, @get_grace_, on her award of her F31! Very well deserved 🤩 will be fun working together to reduce disparities in cardiometabolic prediction!

Sumantra Chatterjee, PhD, hosted Michael Wangler, MD, at the Center on December 12th for a special seminar. Dr. Wangler presented his topic of "Exploring Genetic Mechanisms of Undiagnosed and Rare childhood disease using Drosophila”. Thank you for joining us, Michael Wangler!

youtu.be/A9t_SmoaJWs?si… A summary of a special family enrolled in one of the collaborative projects Texas Children's supported by CZI Science

🚨CME credit available! Check out Dr. Michael Wangler from BCM Department of Molecular and Human Genetics discuss his lab's research studying the clinical phenotypic spectrum of symptoms seen in DNM1L-related disorders, symptoms including epilepsy, neuropathy, and optic atrophy. 🔗Watch here: bit.ly/3WugoMl

If your lab science was like a restaurant and the peer reviewers were restaurant critics you’d expect them to say things like this dish was too dry and should be made this way, or this restaurant claims to serve this but it’s actually that. But some don’t do that. What they do

Congratulations, Dr. K. King Katherine King MDPhD, recipient of the 2025 SPR Award in Honor of E. Mead Johnson recognizing outstanding #pediatricResearch achievements! BCMHouston Texas Children's TCHResearchNews #pediatricsInfectiousDisease societyforpediatricresearch.org/2025-award-rec…

How should we go about discovery in science in four easy steps: Step 1. Based on available evidence propose a hypothesis about some aspect of nature. Don’t listen to those who try to shoot it down right away because it isn’t dogma. Aren’t we trying to discover new things? Do

This is GOLD! How science should always be done…systematically testing meaningful hypotheses. So simple, yet so profound. Thank you, Michael Wangler!

A nice demonstration of peroxisomes in chronic disease. The role of Peroxisome in Diabetic Neuropathy pubmed.ncbi.nlm.nih.gov/39934809/

Biology papers be like "The nucleus is part of the cell and contains a lot of DNA. Polycomb Repressive Complex 2 (PRC2)-mediated deposition of H3K27me3 establishes domains of facultative heterochromatin, silencing gene expression in a developmentally regulated manner."

If you can get your hands on this little book I highly recommend. J. Maynard Smith explores NON STATISTICAL math ideas in biology and it’s just great fun (what parts I understand)

Really interested in asking AGI to solve some biomedical problems with pure mathematical formulas. But my guess is AGI will respond: “I’m sorry, biology represents a complex system that arose through evolution, mathematical formulas have limited predictive power. Please input 500

Impact Statement: Completion of this Specific Aim will make us know more than you can possibly imagine