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"CRISPRi tends to detect genes that are physically closer to regulatory variants and more constrained, whereas eQTL studies are sensitive to detecting multiple, often distal, genes." a.k.a. CRISPRi detects the actual causal gene and eQTLs don't?

Can't have open genomes because something something far-right.

Genomics of schizophrenia, bipolar disorder and major depressive disorder | Nature Reviews Genetics nature.com/articles/s4157…

Free in-person registration is open for #MLCB2025! Sept 10-11 at NY Genome Center and online at youtube.com/@mlcbconf. Paper/abstract deadline is June 1, more deets including our fantastic invited speaker lineup at mlcb.org! Please RP.

We have reached a sale agreement with Regeneron, a leading US-based biotechnology company, to carry forward 23andMe’s mission and maintain customer privacy protections. Read more about today’s announcement here: 23and.me/3ZoX2JT

Interesting perspective relevant to the question: how valuable is one person's genetic information? The 23andMe sale price suggests a very precise number: $17 (obviously a tongue-in-cheek calculation given huge caveats and assumptions, but still)

Fascinating that there's basically no genetic assortative mating for Big Five personality traits.

Electrical stimulation of the spinal cord can reignite movement years after stroke. Fascinating Nature Medicine study showed epidural stimulation of cervical dorsal roots enabled two individuals to regain functional arm and hand control within days.

I often post about how fast the field of psychiatric genetics is moving🧠🧬 The Psychiatric Genomics Consortium is very active delivering some of the largest GWASs across all human diseases. This review covers genetics of schizophrenia, depression, and bipolar disorder👇

High schoolers think it's funny to self-report being transgender. This makes estimates of trans percentages and other stats unreliable. Students who self-report as trans also frequently report being blind 7-foot-tall crackheads who belong to a gang and never visit the dentist.

A lot of medical research is slowed down by ethics regulations that don't make a difference to patient safety. Experienced this first hand & working on smth to change it. If you are someone who has been slowed down forever by IRBs re for example biospecimen collection pls DM.

Why do people follow rules, even when breaking them has no consequences? New research by Gächter et al. suggests it’s driven by an intrinsic respect for rules and social expectations—not just rewards or punishments. nature.com/articles/s4156…

Interesting how the nearest neighbors don’t actually look like the nearest neighbors in 2d 🧐

Here is the problem with "oh no, we're defunding universities, all the smart people are going to go away" Our universities are not really filled with the best and brightest. Even in many of the technical fields, we are spending billions of dollars on a lot of "science" that just

Polygenic risk score (PRS) tools are getting better and better! Yue Li & team at McGill report a major update to their PRS software, VIPRS (variational inference of polygenic risk scores) — now lightning fast & ultra-efficient. VIPRS reads ultra-compressed LD matrices (MBs not

Exciting new Alzheimer’s disease findings presented today by neuroscientist and physicist Jaeseung Jeong 정재승 정재승 Jaeseung Jeong, Ph.D who visited us today at the Marina with his team from KAIST in Korea 💡Tau deposition in dementia is known to occur, but there are 4 subtypes with distinct

One theme of non-coding findings that I like is non-coding mutations in regulatory elements having effect as severe as deleting the gene itself. Here is a nice example of a Mendelian disease caused by haploinsufficiency due to deletion of a regulatory element: Axenfeld-Rieger

📣New from Añorve-Garibay et al! 📄Natural selection acting on complex traits hampers the predictive accuracy of polygenic scores in ancient samples cell.com/ajhg/abstract/…

Yeah, isn't it funny that capitalism works so amazingly well in so many areas, but in one of the few areas the government micromanages, the whole system goes haywire and costs explode. Must be coincidence, I guess.

🚀 Xaira Therapeutics has just dropped a game-changer for AI-driven biology. Today, we unveiled X-Atlas/Orion, the largest publicly available genome-wide Perturb-seq dataset to date—spanning 8.4 million single cells with perturbations across all ~20,000 human protein-coding