In 1992, Burkholder and others first identified Pfiesteria as the toxic dinoflagellate related with fish deaths with associated “punched out” lesions, in the estuaries of the Pamlico and Neuse on the Atlantic seaboard.

References: 1. Fog Nielsen, K., Mycotoxin production by indoor molds. Fungal Genetics and Biology, 2003. 39(2): p.103–117. 2. Thrasher, J.D. and S. Crawley, The biocontaminants and complexity of damp indoor spaces: More than what meets the eyes.

Mycotoxin induced alterations: ✔️regulate the secretion of proinflammatory cytokines such as IL-8 by IECs, ✔️increase production of IgA against microflora and autoantigens, ✔️disturb Th1/Th2 immune response balance.

Butyrate SB decreases yeast biofilm formation and enhances the activity of macrophages by increasing their production of reactive oxygen species.

A study of 918 children who were younger than 12 years old, experienced relief from restlessness and dyssomnia while using lemon balm and valerian root.

Topical GS is advised to use for peripheral meniscus tears in patients with chondromalacia patella, and Osteoarthritis of the great toe, thumb, and fingers. GS should be applied two to three times each day over the joint line areas.

In a preliminary human clinical trial, 26 men with prostate cancer were randomly assigned to receive lycopene (15 mg twice a day) or not any lycopene for three weeks before undergoing prostate surgery. Prostate tissue was then obtained during surgery and examined.

Phosphatidylcholine (PC) is the most abundant phospholipid of the cell membrane and plays an important role in detoxification. A ratio of balanced essential fatty acids (4:1 omega-6 to omega-3 oil) provides cellular nourishment for healthy membrane function.

✔️ The Wisconsin Sleep Cohort Study showed that participants with less sleep had decreased leptin levels and elevated ghrelin [3]. Leptin signals satiety and ghrelin mediate hunger, the higher rates of obesity were attributed to excess caloric intake.

📍Shorter dinner-to-bedtime has been correlated with an increased risk of GERD. Ideally, a gap of 4 hours between eating and sleeping is advised [20].

📍St. John’s wort Used in combination with black cohosh, a synergistic effect was capable of improving insomnia, depression, mood swings, and irritability . .

Electromagnetic Hypersensitivity (EHS) is correlated to the bioaccumulation of toxicants from a number of possible exposures to toxic chemicals/metals, molds, surgical implants, pathogens, amalgams, and radioactive compounds— known as sensitivity-related illness (SRI)

Lipids formed from fatty acids contribute to 60–80% of the central nervous system and need to be continually replenished. Deficiency allows the nervous system to be vulnerable to fat-soluble metals, such as metallic mercury, which can come from amalgam fillings.

Lyme spirochetes evade the host’s immune mechanisms and deplete the host of nutrients. This often leads to the formation of hemopyrollactams and inefficient heme molecules.

GALECTIN-3 • As our survival protein, galectin-3 is produced by the body when we experience threats like injury, infection, toxin exposure, or stress. • Galectin-3 instigates a cascade of inflammatory reactions as part of the repair process.

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