For those bioinformaticians who drown in genomic datasets and are asked to turn them into a paper, we present HiCognition: a visual exploration and hypothesis testing tool for 3D genomics. 🪄hicognition.com #3DGenome #bioinfo #ComputationalBiology #genomics #BioVis

HiCognition allows data analysis of genomic datasets based on the genomic region-set approach. Combined with efficient preprocessing and interactive data visualization, this enables rapid exploration. HiCognition #3DGenome #bioinfo #ComputationalBiology #genomics #scicomm 1/5

Our new preprint about @HiCognition: a visual exploration and hypothesis testing tool for 3D genomics is out: biorxiv.org/content/10.110…. Congratulations to cchlanger and Michael Mitter for developing this fantastic software. #3DGenome #biology #bioinfo #genomics #DNA #chromatin

So excited to finally see Pore-C out in the wild. Great collaboration with Marcin Imieliński Addy Deshpande (perspectivist_) and of course our very own Eoghan Harrington Dan_Turner . Protocol is on Oxford Nanopore website #ONT_Applications nature.com/articles/s4158…

Proud bioinformatician cchlanger presenting our new visualisation tool HiCognition at today’s IMP / IMBA imbavienna.bsky.social PhD & PostDoc day 🧬

Genes—like early explorers who braved the seas—can also embark on extraordinary journeys. It is now clear that horizontal gene transfer takes place even between highly divergent animals species! 🐛🦋🪱🐟. But how exactly does it happen? Find it out in our latest preprint!

If you are interested in developing computational approaches to understand 3D genome organization, get in touch!

Hot off the press nature! "A mitotic chromatin phase transition prevents perforation by microtubules". Our work on mitotic chromosome formation, a tweetorial: In #collaboration with bryan gibson, Shotaro Otsuka + the lab of Mike Rosen @UTSWNews 1/6 nature.com/articles/s4158…

Delighted to share our work, out today, on the roles of histone deacetylation and condensins in shaping mitotic chromosomes. Check out the tweetorial and paper: doi.org/10.1038/s41586…

🧵Here’s a tweetorial on our latest work on the distinct transcriptional roles of chromatin remodelers in Drosophila. Thanks to Alexander Stark and all the members of the StarkLab who made this possible.

The Gerlich lab is hiring! We are looking for a Research Technician to join our team IMBA imbavienna.bsky.social, Vienna BioCenter. For more info and to apply: imba.onlyfy.jobs/job/oawqg61s

Pleased to introduce our latest preprint, out now: “Cohesin-mediated DNA loop extrusion resolves sister chromatids in G2 phase”. We present new quantitative assays probing the conformation of replicated chromosomes by imaging and high-throughput DNA sequencing. A tweetorial: 1/9

First authors Manuel Alonso Y Adell (l) and Tamara Klockner (r) were able to recapitulate some of the aneuploidy patterns seen in cancer and identified specific genes responsible for the selection of certain aneuploidies. Link to the publication: bit.ly/3KRdZ9s Universität Wien

In our latest paper, we use imaging and high-throughput DNA sequencing to probe the confirmation of replicated chromosomes. Read about how cohesin is able to resolve sisters through LE - and more - in our manuscript, published this week in The EMBO Journal (1/2)

We at Open2C are looking for a journal for two of our manuscripts on software tools for Hi-C data analysis: pairtools (biorxiv.org/content/10.110…) and cooltools (biorxiv.org/content/10.110…)!

And we’re #hiring! abdenlab.org Attention #CompBio #postdoc candidates! We have projects focused on #3DGenomics, #Multiomics in human health, #aiml developing and applying both foundational infra and cutting-edge approaches. Apply here: ummsjobs.com/job/10102/